卡氏肺孢子虫在细胞培养中的生物学特性及对抗肺孢子虫药物的反应
Biological profile and response to anti-pneumocystis agents of Pneumocystis carinii in cell culture.
作者信息
Pifer L L, Pifer D D, Woods D R
出版信息
Antimicrob Agents Chemother. 1983 Nov;24(5):674-8. doi: 10.1128/AAC.24.5.674.
Abstract
Although the growth characteristics of Pneumocystis carinii have been described in several cell culture systems, the response of this organism to the drugs of choice, trimethoprim-sulfamethoxazole and pentamidine isethionate, have not been described in vitro. The effect of various concentrations of drugs against P. carinii on the growth of this potentially hazardous opportunistic organism as well as the methodology for in vitro assay of these agents have been detailed. Fluorescence profiles illustrating size ranges of trophozoites and cysts derived from cell culture are described.
摘要
虽然在多种细胞培养系统中已描述了卡氏肺孢子虫的生长特性，但该生物体对首选药物甲氧苄啶-磺胺甲恶唑和戊烷脒异硫氰酸盐的反应尚未在体外进行描述。已详细说明不同浓度药物对卡氏肺孢子虫的作用以及这些药物的体外测定方法。还描述了显示源自细胞培养的滋养体和包囊大小范围的荧光图谱。
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