Liu Ling-Yun, Lu Yanxia, Shen Liang, Li Chun-Bo, Yu Jin-Tai, Yuan Chua Ru, Ye Kaisy Xinhong, Chao Yin Xia, Shen Qing-Feng, Mahendran Rathi, Kua Ee Heok, Yu De-Hua, Feng Lei
Department of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Department of Medical Psychology and Ethics, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
J Psychiatr Res. 2021 Nov 25;145:111-117. doi: 10.1016/j.jpsychires.2021.11.041.
The prevalence of dementia has been widely reported, and its potential risk and protective factors are well-characterized. However, there is a scarcity of related information regarding mild cognitive impairment (MCI). Thus this population-based study aimed to determine the prevalences of MCI and its subtypes, as well as to identify the risk and protective factors for MCI in the Chinese elderly population of Singapore. Results showed that the overall prevalence of MCI was 12.5%, while the gender-adjusted prevalence of MCI was 12.3%. Gender was found to be significantly associated with the subtypes of MCI, with males more likely to have amnestic MCI and females more likely to have non-amnestic MCI. Older age, lower educational levels, lower social activity levels, depression, hypertension, hyperlipidemia, diabetes and stroke were found to be risk factors for MCI in univariate analysis. However, multivariable analysis showed that only hypertension and stroke were the significant risk factors for MCI. Higher educational levels and active social engagements were significant protective factors for MCI in multivariable analysis. Age and depression had boundary significant associations with the prevalence of MCI. After adjusting for gender, the influence of hypertension, stroke, social engagement, age and depression on MCI remained unchanged, except that education became a boundary significant lower risk factor of MCI development. In conclusion, this study presented the prevalence, risk and protective factors for MCI among Singaporean Chinese older adults, which facilitates the screening of vulnerable groups for MCI.
痴呆症的患病率已有广泛报道，其潜在风险和保护因素也已得到充分描述。然而，关于轻度认知障碍（MCI）的相关信息却很匮乏。因此，这项基于人群的研究旨在确定MCI及其亚型的患病率，并识别新加坡华裔老年人群中MCI的风险和保护因素。结果显示，MCI的总体患病率为12.5%，而经性别调整后的患病率为12.3%。研究发现，性别与MCI的亚型显著相关，男性更易患遗忘型MCI，女性更易患非遗忘型MCI。在单因素分析中，年龄较大、教育水平较低、社交活动水平较低、抑郁、高血压、高脂血症、糖尿病和中风被发现是MCI的风险因素。然而，多变量分析表明，只有高血压和中风是MCI的显著风险因素。在多变量分析中，较高的教育水平和积极的社交参与是MCI的显著保护因素。年龄和抑郁与MCI的患病率有临界显著关联。在调整性别因素后，高血压、中风、社交参与、年龄和抑郁对MCI的影响保持不变，只是教育成为MCI发展的一个临界显著低风险因素。总之，本研究呈现了新加坡华裔老年人中MCI的患病率、风险和保护因素，这有助于筛查MCI的弱势群体。
