Department of Pharmacognosy, College of Pharmacy, Cairo University, Cairo, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Nat Prod Res. 2022 Nov;36(22):5766-5771. doi: 10.1080/14786419.2021.2013836. Epub 2021 Dec 13.
, , and were acquired from the Egyptian market, profiled for their chemical constituents, screened for the MAO-B inhibitory activity and evaluated for the total phenolic content. Thirty compounds were characterized in the selected herbs using HPLC-MS/MS. MAO-B inhibitory activity and total phenolic content of the acquired herbs were compared with those of a prepared herbal formula consisting of a mixture of equal amounts of the four mentioned herbs. The most potent MAO-B inhibitory activity was exerted by the methanol extract of the prepared formula (IC of 712.19 ± 13.90 ng/mL) compared to selegiline (IC of 581.69 ± 11.35 ng/mL). The highest value of the total phenolic content was shown by methanolic extract (76.15 ± 0.1 mg/g) followed by methanolic extract (65.74 ± 0.1 mg/g), then the mixture's methanolic extract of the four herbs (37.04 ± 0.1 mg/g).
、、和从埃及市场获得，对其化学成分进行了分析，筛选出 MAO-B 抑制活性，并评估了总酚含量。使用 HPLC-MS/MS 在选定的草药中鉴定了 30 种化合物。所获得的草药的 MAO-B 抑制活性和总酚含量与由四种草药等量混合而成的草药配方的活性和含量进行了比较。与司来吉兰（IC50 为 581.69 ± 11.35ng/mL）相比，制备配方的甲醇提取物表现出最强的 MAO-B 抑制活性（IC50 为 712.19 ± 13.90ng/mL）。总酚含量最高的是提取物（76.15 ± 0.1mg/g），其次是提取物（65.74 ± 0.1mg/g），然后是四种草药混合物的甲醇提取物（37.04 ± 0.1mg/g）。
