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通过体内伏安法测量的亚秒级纹状体多巴胺释放。

Sub-second striatal dopamine release measured by in vivo voltammetry.

作者信息

Stamford J A, Kruk Z L, Millar J

出版信息

Brain Res. 1986 Sep 3;381(2):351-5. doi: 10.1016/0006-8993(86)90087-9.

DOI:10.1016/0006-8993(86)90087-9
PMID:3489507
Abstract

High speed cyclic voltammetry was used to measure electrically stimulated striatal dopamine release in vivo with 25 ms time resolution. Dopamine release after 1 s stimulations was readily detectable and could be manipulated by drugs known to influence dopaminergic neurones. Using data-averaging dopamine release could be detected following stimulus trains as short as 100 ms. The use of carbon fibre microelectrodes gave a spatial resolution better than 5 micron.

摘要

高速循环伏安法用于在体内以25毫秒的时间分辨率测量电刺激纹状体多巴胺释放。1秒刺激后的多巴胺释放很容易检测到,并且可以被已知影响多巴胺能神经元的药物所调控。通过数据平均,在短至100毫秒的刺激序列后也能检测到多巴胺释放。使用碳纤维微电极可获得优于5微米的空间分辨率。

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