Mental Health Centre, General Hospital of Ningxia Medical University, No. 804 South Shengli Street, Yinchuan, 750004, Ningxia, China.
Ningxia Medical University, No.1106 South Shengli Street, Yinchuan, 750004, China.
BMC Psychiatry. 2021 Dec 11;21(1):623. doi: 10.1186/s12888-021-03612-5.
The neurodevelopmental model of obsessive-compulsive disorder (OCD) suggests that the neurodevelopmental changes in the ventral striatal circuit of the prefrontal lobe are associated with the initial symptoms of OCD. Facial morphology is one of the most consistent anatomical phenotypes of neurodevelopmental disorders, which can reflect brain structure and function. Facial deformity, an easily measured index of brain malformation, can reflect abnormal brain structure and function. Therefore, this study aims to explore the relationship between clinical features and neurodevelopment of adolescents with OCD through facial morphology.
The enrolled study sample comprised 40 adolescents diagnosed with OCD using the Obsessive Compulsive Inventory-Child Version (OCI-CV) and 38 healthy controls (HCs). Facial photos, 21 facial diameters, and 9 facial angles were collected using image software.
In males, lower lip red height was significantly lower in OCD patients than in HCs (P < 0.025); no significant differences were observed in other facial indicators (all P > 0.025). In females, the nasolabial angle was smaller in OCD patients than in HCs (P < 0.025); no significant differences were observed in other facial indicators (all P > 0.025). The difference in lower lip red height between the OCD group and HC group was positively correlated with neutralizing symptoms (r = 0.401, P < 0.05).
Male OCD patients had a thinner lower lip and female OCD patients had smaller nasolabial angles. The facial features of adolescents with OCD were positively correlated with lower lip redness and neutralizing symptoms.
强迫症（OCD）的神经发育模型表明，前额叶腹侧纹状体回路的神经发育变化与 OCD 的初始症状有关。面部形态是神经发育障碍最一致的解剖表型之一，它可以反映大脑结构和功能。面部畸形是大脑畸形的一个易于测量的指标，它可以反映异常的大脑结构和功能。因此，本研究旨在通过面部形态探讨强迫症青少年的临床特征与神经发育之间的关系。
研究纳入了 40 名经儿童强迫症量表（OCI-CV）诊断为强迫症的青少年患者和 38 名健康对照者（HCs）。使用图像软件采集面部照片、21 个面部直径和 9 个面部角度。
在男性中，强迫症患者的下唇红高度明显低于 HCs（P<0.025）；其他面部指标无显著差异（均 P>0.025）。在女性中，强迫症患者的鼻唇角小于 HCs（P<0.025）；其他面部指标无显著差异（均 P>0.025）。强迫症组与 HCs 组下唇红高度的差异与中和症状呈正相关（r=0.401，P<0.05）。
男性强迫症患者的下唇较薄，女性强迫症患者的鼻唇角较小。强迫症青少年的面部特征与下唇红度和中和症状呈正相关。
