比较采用标准化刺激方案进行体外受精的中国和白种妇女在卵巢刺激后获得的卵母细胞数量。
Comparison of the number of oocytes obtained after ovarian stimulation between Chinese and Caucasian women undergoing in vitro fertilization using a standardized stimulation regime.
机构信息
Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
IVF Australia, Sydney, Australia.
出版信息
J Ovarian Res. 2021 Dec 11;14(1):175. doi: 10.1186/s13048-021-00928-4.
BACKGROUND
In vitro fertilization (IVF) is a well-established method to treat various causes of infertility. Some previous retrospective studies suggested a lower ovarian response in Asian women compared to Caucasian women. However, the ovarian stimulation regimens were not standardized, potentially confounding the findings. The objective of this study is to compare the number of oocytes obtained after ovarian stimulation between Chinese and Caucasian women undergoing IVF using a standardized stimulation regimen.
METHODS
This is a prospective cohort study conducted in two tertiary IVF units in Hong Kong, China and Sydney, Australia from October 2016 to August 2019. A total of 192 women aged 18-42 years with a body weight > 60 kg underwent IVF with a standard ovarian stimulation regimen of 150 micrograms corifollitropin alfa (Elonva®) followed by 200 IU follitropin beta (Puregon®) per day. The number of oocytes retrieved in Chinese women treated in the Hong Kong center was compared to that of Caucasian women treated in the Australian center.
RESULTS
Serum AMH levels were similar between the two groups. Although women in the Chinese cohort were older and had a higher body mass index (BMI), longer duration of infertility and lower antral follicle count (AFC) than those in the Caucasian cohort in this study, no differences in the number of oocytes retrieved [11 (8-17) vs. 11 (6-17), p=0.29], total dosage and duration of stimulation and number of follicles aspirated were noted between the two ethnic cohorts. The peak estradiol level was greater in Chinese women than in Caucasian women. After controlling for age, BMI and AFC, ethnicity was a significant independent determinant of the number of oocytes obtained.
CONCLUSIONS
Chinese women had a higher number of oocytes after ovarian stimulation using a standardized stimulation regimen compared with Caucasian women undergoing IVF after controlling for age, BMI, AFC and AMH despite presenting later after a longer duration of infertility.
TRIAL REGISTRATION NUMBER
NCT02748278.
背景
体外受精（IVF）是治疗各种不孕原因的成熟方法。一些先前的回顾性研究表明，亚洲女性的卵巢反应低于白种人女性。然而，卵巢刺激方案并未标准化，这可能会影响研究结果。本研究的目的是比较使用标准化刺激方案进行 IVF 的中国女性和白种人女性在卵巢刺激后获得的卵母细胞数量。
方法
这是一项在中国香港和澳大利亚悉尼的两个三级 IVF 单位进行的前瞻性队列研究。2016 年 10 月至 2019 年 8 月期间，共 192 名年龄在 18-42 岁、体重 > 60kg 的女性接受了 IVF 治疗，采用标准卵巢刺激方案，每天给予 150μg 戈那瑞林（Elonva®）和 200IU 促卵泡激素β（Puregon®）。比较了香港中心治疗的中国女性与澳大利亚中心治疗的白种人女性的取卵数量。
结果
两组血清 AMH 水平相似。尽管在这项研究中，中国队列的女性年龄较大，体重指数（BMI）较高，不孕时间较长，窦卵泡计数（AFC）较低，但与白种人队列相比，取卵数量[11（8-17）与 11（6-17），p=0.29]、刺激总剂量和持续时间以及抽吸的卵泡数量无差异。中国女性的雌二醇峰值水平高于白种人女性。在控制年龄、BMI 和 AFC 后，种族是获得卵母细胞数量的显著独立决定因素。
结论
尽管在不孕时间较长后就诊较晚，但在中国女性和白种人女性中，在控制年龄、BMI、AFC 和 AMH 后，使用标准化刺激方案进行 IVF 治疗的中国女性卵巢刺激后获得的卵母细胞数量更高。
试验注册号
NCT02748278。
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