老年大鼠体内内源性致热原/白细胞介素-1的产生
Endogenous pyrogen/interleukin-1 production in aged rats.
作者信息
Kauffman C A
出版信息
Exp Gerontol. 1986;21(2):75-8. doi: 10.1016/0531-5565(86)90055-0.
PMID:3489633
Abstract
The effect of aging on the ability of macrophages to produce endogenous pyrogen/interleukin-1 (EP/IL-1) was tested in 13 young adult (2-3 mo) and 13 aged (24-26 mo) Fischer rats using a febrile response assay. Peritoneal macrophages from aged rats produced EP/IL-1 as well as young adult rats. Decreased production of EP/Il-1 does not appear to explain the diminished febrile response seen in the elderly.
摘要
利用发热反应测定法，在13只年轻成年（2 - 3个月）和13只老年（24 - 26个月）的费希尔大鼠中，测试了衰老对巨噬细胞产生内源性致热原/白细胞介素-1（EP/IL-1）能力的影响。老年大鼠的腹腔巨噬细胞产生EP/IL-1的情况与年轻成年大鼠一样。EP/Il-1产生量的减少似乎并不能解释老年人发热反应减弱的现象。
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