Department of Pathology, Uijeongbu Eulji University Center, Eulji University School of Medicine, Uijeongbu-si 11759, Korea.
Department of Internal Medicine, Uijeongbu Eulji University Center, Eulji University School of Medicine, Uijeongbu-si 11759, Korea.
Curr Oncol. 2021 Nov 1;28(6):4367-4376. doi: 10.3390/curroncol28060371.
This study aimed to elucidate the prognostic implications of intratumoral and peritumoral infiltrating T-lymphocytes in pancreatic ductal adenocarcinoma (PDAC) through a meta-analysis. A total of 18 eligible studies and 2453 PDAC patients were included in the present study. Intratumoral and peritumoral infiltrating lymphocytes were evaluated using various markers, such as CD3, CD4, CD8, FOXP3, and immune cell score. The correlations between these parameters and overall and disease-free survival were investigated and used in the meta-analysis. High intratumoral infiltration of CD3-, CD4-, and CD8-expressing lymphocytes was significantly correlated with better overall survival (hazard ratio (HR) 0.747, 95% confidence interval (CI) 0.620-0.900, HR 0.755, 95% CI 0.632-0.902, and HR 0.754, 95% CI 0.611-0.930, respectively). However, there was no significant correlation between PDAC prognosis and intratumoral FOXP3 or immune cell score (HR 1.358, 95% CI 1.115-1.655 and HR 0.776, 95% CI 0.566-1.065, respectively). Moreover, there was no significant correlation between the prognosis and peritumoral infiltrating T-lymphocytes. In evaluations of disease-free survival, only high intratumoral CD4 infiltration was correlated with a better prognosis (HR 0.525, 95% CI 0.341-0.810). Our results showed that high intratumoral infiltrating lymphocytes were significantly correlated with a better PDAC prognosis. However, among the tumor-infiltrating lymphocytes, CD3, CD4, and CD8 had prognostic implications, but not FOXP3 and immune cell score.
本研究通过荟萃分析旨在阐明胰腺导管腺癌（PDAC）肿瘤内和肿瘤周围浸润性 T 淋巴细胞的预后意义。本研究共纳入了 18 项符合条件的研究和 2453 例 PDAC 患者。使用各种标志物（如 CD3、CD4、CD8、FOXP3 和免疫细胞评分）评估肿瘤内和肿瘤周围浸润的淋巴细胞。研究了这些参数与总生存期和无病生存期之间的相关性，并将其用于荟萃分析。高肿瘤内浸润的 CD3+、CD4+和 CD8+表达淋巴细胞与更好的总生存期显著相关（风险比（HR）0.747，95%置信区间（CI）0.620-0.900，HR 0.755，95% CI 0.632-0.902 和 HR 0.754，95% CI 0.611-0.930）。然而，PDAC 预后与肿瘤内 FOXP3 或免疫细胞评分之间没有显著相关性（HR 1.358，95% CI 1.115-1.655 和 HR 0.776，95% CI 0.566-1.065）。此外，肿瘤周围浸润性 T 淋巴细胞与预后之间也没有显著相关性。在无病生存期评估中，只有高肿瘤内 CD4 浸润与更好的预后相关（HR 0.525，95% CI 0.341-0.810）。我们的结果表明，高肿瘤内浸润性淋巴细胞与 PDAC 的较好预后显著相关。然而，在肿瘤浸润淋巴细胞中，CD3、CD4 和 CD8 具有预后意义，但 FOXP3 和免疫细胞评分则没有。
