Department of Hepatobiliary Surgery, The Second Affiliated Hospital of JiaXing University, Jiaxing, 314000, Zhejiang, China.
World J Surg Oncol. 2021 Oct 16;19(1):300. doi: 10.1186/s12957-021-02420-1.
Tumor-infiltrating lymphocytes (TILs) are major participants in the tumor microenvironment. The prognostic value of TILs in patients with pancreatic cancer is still controversial.
The aim of our meta-analysis was to determine the impact of FoxP3+Treg cells on the survival of pancreatic cancer patients. We searched for related studies in PubMed, EMBASE, Ovid, and Cochrane Library from the time the databases were established to Mar 30, 2017. We identified studies reporting the prognostic value of FoxP3+Treg cells in patients with pancreatic cancer. Overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS)/relapse-free survival (RFS) were investigated by pooling the data. The pooled hazard ratios (HRs) with 95% confidence intervals (95% CI) were used to evaluate the association between FoxP3+Treg cells and survival outcomes of pancreatic cancer patients. A total of 972 pancreatic cancer patients from 8 studies were included in our meta-analysis.
High levels of infiltration with FoxP3+Treg cells were significantly associated with poor OS (HR=2.13; 95% CI 1.64-2.77; P<0.05) and poor DFS/PFS/RFS (HR=1.70; 95% CI 1.04 ~ 2.78; P< 0.05). Similar results were also observed in the peritumoral tissue; high levels of FoxP3+Treg cells were associated with poor OS (HR =2.1795% CI, CI 1.50-3.13).
This meta-analysis indicated that high levels of intratumoral or peritumoral FoxP3+Treg cell infiltration could be recognized as a negative factor in the prognosis of pancreatic cancer.
肿瘤浸润淋巴细胞（TILs）是肿瘤微环境的主要参与者。TILs 在胰腺癌患者中的预后价值仍存在争议。
本荟萃分析的目的是确定 FoxP3+Treg 细胞对胰腺癌患者生存的影响。我们从各数据库建立开始到 2017 年 3 月 30 日，在 PubMed、EMBASE、Ovid 和 Cochrane Library 中搜索了相关研究。我们确定了报道 FoxP3+Treg 细胞在胰腺癌患者中预后价值的研究。通过汇总数据来研究总生存（OS）和无病生存（DFS）/无进展生存（PFS）/无复发生存（RFS）。使用合并的风险比（HR）及其 95%置信区间（95%CI）来评估 FoxP3+Treg 细胞与胰腺癌患者生存结局之间的关系。共有 8 项研究中的 972 名胰腺癌患者纳入本荟萃分析。
高水平的 FoxP3+Treg 细胞浸润与较差的 OS（HR=2.13；95%CI 1.64-2.77；P<0.05）和较差的 DFS/PFS/RFS（HR=1.70；95%CI 1.04-2.78；P<0.05）显著相关。在肿瘤周围组织中也观察到了类似的结果；高水平的 FoxP3+Treg 细胞与较差的 OS 相关（HR=2.1795%CI，CI 1.50-3.13）。
本荟萃分析表明，肿瘤内或肿瘤周围 FoxP3+Treg 细胞浸润水平较高可被认为是胰腺癌预后的一个负面因素。
