Sheng Minjie, Cai Haiying, Yang Qin, Li Jing, Zhang Jian, Liu Lihua
Department of Ophthalmology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Genet. 2021 Nov 25;12:792754. doi: 10.3389/fgene.2021.792754. eCollection 2021.
Lymphoma is a serious type of cancer, especially for adolescents and elder adults, although this malignancy is quite rare compared with other types of cancer. The cause of this malignancy remains ambiguous. Genetic factor is deemed to be highly associated with the initiation and progression of lymphoma, and several genes have been related to this disease. Determining the pathogeny of lymphoma by identifying the related genes is important. In this study, we presented a random walk-based method to infer the novel lymphoma-associated genes. From the reported 1,458 lymphoma-associated genes and protein-protein interaction network, raw candidate genes were mined by using the random walk with restart algorithm. The determined raw genes were further filtered by using three screening tests (i.e., permutation, linkage, and enrichment tests). These tests could control false-positive genes and screen out essential candidate genes with strong linkages to validate the lymphoma-associated genes. A total of 108 inferred genes were obtained. Analytical results indicated that some inferred genes, such as , , , , , , , , were associated with the initiation and progression of lymphoma.
淋巴瘤是一种严重的癌症类型，对青少年和老年人尤其如此，尽管与其他类型的癌症相比，这种恶性肿瘤相当罕见。这种恶性肿瘤的病因仍不明确。遗传因素被认为与淋巴瘤的发生和发展高度相关，并且有几个基因已与该疾病相关联。通过识别相关基因来确定淋巴瘤的发病机制很重要。在本研究中，我们提出了一种基于随机游走的方法来推断新的淋巴瘤相关基因。从已报道的1458个淋巴瘤相关基因和蛋白质-蛋白质相互作用网络中，使用带重启的随机游走算法挖掘原始候选基因。通过三种筛选测试（即置换、连锁和富集测试）对确定的原始基因进行进一步筛选。这些测试可以控制假阳性基因，并筛选出具有强关联性的重要候选基因，以验证淋巴瘤相关基因。总共获得了108个推断基因。分析结果表明，一些推断出的基因，如 、 、 、 、 、 、 、 ，与淋巴瘤的发生和发展相关。 （原文中部分基因名称缺失，翻译时保留原样）
