George Sophia H L, Omotoso Ayodele, Pinto Andre, Mustapha Aisha, Sanchez-Covarrubias Alex P, Umar Usman Aliyu, Umar Ali Bala, Oluwasola Timothy Abiola, Okolo Clement Abu, Anthony Umeh Uchenna, Ukekwe Francis Ikechukwu, Bakari Maisaratu A, Dahiru Aminu M C, Abdullahi Habiba Ibrahim, Abimiku Bawa Ahmed, Abdurrahman Aisha, Usman Asmau, Ahmed Saad Aliyu, Usman Hadiza Abdullahi, Kabir Abba, Eleje George Uchenna, Chiemeka Michael Emeka, Nzeribe Emily, Nweke Ikechukwu, Kadas SaiduAbubakar, Suleiman Dauda E, Ekanem Etim, Uche Umemmuo Maureen, Paul Jibrin, Agwu Uzoma Maryrose, Edegbe Felix O, Anorlu Rose I, Banjo Adekunbiola, Ajenifuja Kayode Olusegun, Fawole Adegboyega Adisa, Kazeem Ibrahim O O, Magaji Francis, Silas Olugbenga, Athanasius Boma Precious, Tamunomie Nyengidiki Kennedy, Bassey Emem, Abudu Kunle, Ango Ibrahim G, Abdullahi Kabiru, Lawal Ishak, Kabir Suleiman Aliyu, Ekanem Victor, Ezeanochie Michael, Yahaya Usman Rahman, Castillo Melissa Nicole, Bahall Vishal, Chatrani Vikash, Brambury Ian, Bowe Saida, Halliday Darron, Bruney George, Butler Raleigh, Ragin Camille, Odedina Folakemi, Chamala Srikar, Schlumbrecht Matthew, Audu Bala
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States.
African Caribbean Cancer Consortium, Philadelphia, PA, United States.
Front Oncol. 2021 Nov 26;11:732443. doi: 10.3389/fonc.2021.732443. eCollection 2021.
Ovarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora.
Patients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student's t-test with significance set at p<0.05.
Nigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01).
There is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.
在许多西非国家，黑人女性患卵巢癌很常见，但在北美相对少见。与白人女性相比，黑人女性的生存结果更差。卵巢癌的组织学类型、诊断情况及确诊时的年龄是已知的预后因素。我们试图对散居在非洲各地的人群中的这些因素进行初步比较评估。
确定2016年6月至2019年12月期间在尼日利亚25个参与研究的病理科被诊断为卵巢癌（所有组织学类型）的患者。还从国际癌症研究机构和佛罗里达癌症数据系统获取了基于人群的比较数据，包括出生在加勒比地区的黑人（CBB）和出生在美国的黑人（USB）。收集并评估了三个亚组（USB、CBB和尼日利亚人）的组织学类型、出生国家及确诊年龄数据。采用卡方检验和学生t检验进行统计分析，显著性设定为p<0.05。
相对于CBB和USB，尼日利亚人患生殖细胞肿瘤（GCT，11.5%）和性索间质肿瘤（SCST，16.2%）的卵巢癌比例最高（p=0.001）。CBB（79.4%）和USB（77.3%）女性被诊断为浆液性卵巢癌的比例高于尼日利亚人（60.4%）（p<0.0001）。与USB（58.9 ± 15.0岁）和CBB（59.0± 13.0岁）相比，尼日利亚人被诊断为上皮性卵巢癌的年龄最小（51.7± 12.8岁）（p<0.001）。黑人女性[CBB（25.2 ± 15.0岁）、尼日利亚人（29.5 ± 15.1岁）和USB（33.9 ± 17.9岁）]被诊断为GCT的年龄比白人女性（35.4 ± 20.5岁）小（p=0.011）。黑人女性[尼日利亚人（47.5 ± 15.9岁）、USB（50.9 ± 18.3岁）和CBB（50.9 ± 18.3岁）]被诊断为SCST的年龄也比白人女性（55.6 ± 16.5岁）小（p<0.01）。
散居在非洲各地的人群在卵巢癌确诊年龄及组织学类型/诊断分布方面存在显著差异。这些发现的病因需要进一步研究。
