Soheilifar Mohammad Hasan, Masoudi-Khoram Nastaran, Shirkavand Afshan, Ghorbanifar Shima
Department of Medical Laser, Medical Laser Research Center, Yara Institute, Academic Center for Education, Culture and Research (ACECR), Enghelab St, 1315795613, Tehran, Iran.
Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Biogerontology. 2022 Jun;23(3):289-306. doi: 10.1007/s10522-022-09966-x. Epub 2022 May 19.
The aging of skin is a biological process affected by environmental or genetic factors. Exposure to ultraviolet (UV) radiation is the main environmental factor causing skin aging. Cumulative UV-induced photodamage of the skin tissue is associated with premature cellular senescence, extracellular degradation, and inflammatory responses in photoaging processes. Non-coding RNAs (ncRNAs) are untranslated transcripts and master regulators of protein-coding genes. ncRNAs have a critical regulatory role in maintaining skin structure, skin barrier function, morphogenesis, and development. Altered ncRNA expression has been reported in various skin disorders such as photoaging and skin cancers. ncRNAs contribute to the suppression and promotion of photoaging by modulating signaling pathways such as mitogen-activated protein kinase (MAPK) pathway and regulating inflammatory cytokines, matrix metalloproteinases (MMPs), and senescence-associated genes. Elucidation of the functions of ncRNAs will improve the identification of molecular mechanisms underlying photoaging, and can be used in the development of therapeutic approaches in skin health and prevention of sun-induced aging. This review summarized the currently described ncRNAs and their functions in photoaging.
皮肤老化是一个受环境或遗传因素影响的生物学过程。暴露于紫外线（UV）辐射是导致皮肤老化的主要环境因素。紫外线诱导的皮肤组织累积光损伤与光老化过程中的细胞过早衰老、细胞外降解及炎症反应相关。非编码RNA（ncRNA）是未翻译的转录本，也是蛋白质编码基因的主要调节因子。ncRNA在维持皮肤结构、皮肤屏障功能、形态发生及发育方面具有关键调节作用。据报道，在光老化和皮肤癌等各种皮肤疾病中，ncRNA表达发生改变。ncRNA通过调节丝裂原活化蛋白激酶（MAPK）等信号通路以及调控炎症细胞因子、基质金属蛋白酶（MMP）和衰老相关基因，对光老化起到抑制和促进作用。阐明ncRNA的功能将有助于深入了解光老化的分子机制，并可用于开发皮肤健康治疗方法及预防阳光诱导的老化。本综述总结了目前所描述的ncRNA及其在光老化中的功能。
