• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鼠尾草酸通过线粒体介导的凋亡抑制口腔鳞状细胞癌的发展。

Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma Mitochondrial-Mediated Apoptosis.

作者信息

Min Fenghe, Liu Xin, Li Yuan, Dong Mingyuan, Qu Yidi, Liu Weiwei

机构信息

Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Jilin University, Changchun, China.

Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun, China.

出版信息

Front Oncol. 2021 Nov 26;11:760861. doi: 10.3389/fonc.2021.760861. eCollection 2021.

DOI:10.3389/fonc.2021.760861
PMID:34900710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8662526/
Abstract

Oral squamous cell carcinoma (OSCC) predominantly consists of squamous cells and is the tumor with the highest incidence of the head and neck. Carnosic acid (CA), a natural monomer drug obtained from rosemary and salvia, shows various pharmacological effects, including of tumor development. This study aimed to assess for an effect of CA on the development of OSCC and the underlying mechanisms. In CAL27 and SCC9 cells, CA inhibited cell proliferation and migration, increased intracellular levels of reactive oxygen species (ROS) and Ca, decreased the mitochondrial membrane potential (MMP), and promoted apoptosis. In CAL27- and SCC9-xenotransplanted BALB/c nude mice, CA inhibited the tumor growth without affecting the body weight and tissue morphology. CA upregulated Bax, Bad, cleaved Caspase-3 and -9 levels, and the cleaved PARP1/PARP1 ratio but downregulated Bcl-2 in CA-treated OSCC cells and OSCC cells-xenotransplanted BALB/c nude mice. These results indicate that CA suppresses OSCC at least the mitochondrial apoptotic pathway and offers this natural compound as a potential therapeutic against OSCC.

摘要

口腔鳞状细胞癌（OSCC）主要由鳞状细胞组成，是头颈部发病率最高的肿瘤。迷迭香酸（CA）是一种从迷迭香和丹参中提取的天然单体药物，具有多种药理作用，包括对肿瘤发展的影响。本研究旨在评估CA对OSCC发展的影响及其潜在机制。在CAL27和SCC9细胞中，CA抑制细胞增殖和迁移，增加细胞内活性氧（ROS）和Ca水平，降低线粒体膜电位（MMP），并促进细胞凋亡。在CAL27和SCC9异种移植的BALB/c裸鼠中，CA抑制肿瘤生长，而不影响体重和组织形态。CA上调了经CA处理的OSCC细胞和OSCC细胞异种移植的BALB/c裸鼠中Bax、Bad、裂解的Caspase-3和-9水平以及裂解的PARP1/PARP1比率，但下调了Bcl-2。这些结果表明，CA至少通过线粒体凋亡途径抑制OSCC，并为这种天然化合物作为OSCC的潜在治疗药物提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/64de8a4af90f/fonc-11-760861-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/8d5de1046bee/fonc-11-760861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/a131f2be19d7/fonc-11-760861-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/27c8c8f13425/fonc-11-760861-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/69a65ee38cc9/fonc-11-760861-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/066ed042ba4d/fonc-11-760861-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/64de8a4af90f/fonc-11-760861-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/8d5de1046bee/fonc-11-760861-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/a131f2be19d7/fonc-11-760861-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/27c8c8f13425/fonc-11-760861-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/69a65ee38cc9/fonc-11-760861-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/066ed042ba4d/fonc-11-760861-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e1b/8662526/64de8a4af90f/fonc-11-760861-g006.jpg

相似文献

1
Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma Mitochondrial-Mediated Apoptosis.鼠尾草酸通过线粒体介导的凋亡抑制口腔鳞状细胞癌的发展。
Front Oncol. 2021 Nov 26;11:760861. doi: 10.3389/fonc.2021.760861. eCollection 2021.
2
Induction of ferroptosis by carnosic acid-mediated inactivation of Nrf2/HO-1 potentiates cisplatin responsiveness in OSCC cells.姜酚酸通过抑制 Nrf2/HO-1 发挥作用诱导铁死亡，增强口腔鳞状细胞癌细胞对顺铂的敏感性。
Mol Cell Probes. 2022 Aug;64:101821. doi: 10.1016/j.mcp.2022.101821. Epub 2022 Apr 29.
3
Carnosic acid induces apoptosis of hepatocellular carcinoma cells via ROS-mediated mitochondrial pathway.迷迭香酸通过 ROS 介导的线粒体途径诱导肝癌细胞凋亡。
Chem Biol Interact. 2017 Nov 1;277:91-100. doi: 10.1016/j.cbi.2017.09.005. Epub 2017 Sep 13.
4
Lycorine hydrochloride induces reactive oxygen species-mediated apoptosis via the mitochondrial apoptotic pathway and the JNK signaling pathway in the oral squamous cell carcinoma HSC-3 cell line.盐酸石蒜碱通过线粒体凋亡途径和JNK信号通路诱导口腔鳞状细胞癌HSC-3细胞系中活性氧介导的细胞凋亡。
Oncol Lett. 2021 Mar;21(3):236. doi: 10.3892/ol.2021.12497. Epub 2021 Jan 26.
5
Antitumor activity of 4-O-Methylhonokiol in human oral cancer cells is mediated via ROS generation, disruption of mitochondrial potential, cell cycle arrest and modulation of Bcl-2/Bax proteins.4-O-甲基厚朴酚在人口腔癌细胞中的抗肿瘤活性是通过活性氧生成、线粒体膜电位破坏、细胞周期阻滞以及Bcl-2/Bax蛋白的调节介导的。
J BUON. 2017 Nov-Dec;22(6):1577-1581.
6
[Effect of circular RNA hsa_circ_0063772 on proliferation, migration and invasion of oral squamous cell carcinoma cells].环状RNA hsa_circ_0063772对口腔鳞状细胞癌细胞增殖、迁移和侵袭的影响
Zhonghua Kou Qiang Yi Xue Za Zhi. 2019 Aug 9;54(8):561-567. doi: 10.3760/cma.j.issn.1002-0098.2019.08.011.
7
Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma.甘草查尔酮 D 通过直接靶向 JAK2 诱导人口腔鳞状细胞癌细胞凋亡。
J Cell Physiol. 2019 Feb;234(2):1780-1793. doi: 10.1002/jcp.27050. Epub 2018 Aug 2.
8
Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS.奥沙利铂通过增加 ROS 的产生诱导口腔鳞状细胞癌中的 PARP1 介导的 parthanatos。
Aging (Albany NY). 2021 Jan 20;13(3):4242-4257. doi: 10.18632/aging.202386.
9
The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma.NLRP3炎性小体在口腔鳞状细胞癌对5-氟尿嘧啶耐药中的作用
J Exp Clin Cancer Res. 2017 Jun 21;36(1):81. doi: 10.1186/s13046-017-0553-x.
10
In vitro and in vivo anti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma.二甲双胍作为一种新型治疗药物在人口腔鳞状细胞癌中的体外和体内抗肿瘤作用。
BMC Cancer. 2012 Nov 14;12:517. doi: 10.1186/1471-2407-12-517.

引用本文的文献

1
Bioactive Plant-Derived Compounds as Novel Perspectives in Oral Cancer Alternative Therapy.生物活性植物衍生化合物作为口腔癌替代疗法的新视角
Pharmaceuticals (Basel). 2025 Jul 24;18(8):1098. doi: 10.3390/ph18081098.
2
Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma.天然药用植物活性成分在口腔鳞状细胞癌中的应用。
Chin J Integr Med. 2024 Sep;30(9):852-864. doi: 10.1007/s11655-024-3804-7. Epub 2024 Apr 12.
3
Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment.非黑色素瘤皮肤癌的天然化合物：预防与治疗。

本文引用的文献

1
lncRNA MALAT1 participates in metformin inhibiting the proliferation of breast cancer cell.长链非编码 RNA MALAT1 参与二甲双胍抑制乳腺癌细胞增殖。
J Cell Mol Med. 2021 Aug;25(15):7135-7145. doi: 10.1111/jcmm.16742. Epub 2021 Jun 24.
2
MicroRNA‑198 suppresses tumour growth and metastasis in oral squamous cell carcinoma by targeting CDK4.MicroRNA-198 通过靶向 CDK4 抑制口腔鳞状细胞癌的肿瘤生长和转移。
Int J Oncol. 2021 Jul;59(1). doi: 10.3892/ijo.2021.5219. Epub 2021 May 13.
3
A self-sustained nanoplatform reverses TRAIL-resistance of pancreatic cancer through coactivating of exogenous and endogenous apoptotic pathway.
Molecules. 2024 Feb 4;29(3):728. doi: 10.3390/molecules29030728.
4
Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study.迷迭香作为天然抗氧化剂和抗癌剂的潜在来源：一项分子对接研究。
Plants (Basel). 2023 Dec 27;13(1):89. doi: 10.3390/plants13010089.
5
Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives.探索迷迭香衍生化合物（迷迭香酸和鼠尾草酸）作为癌症治疗药物的潜力：当前知识与未来展望
Biomol Ther (Seoul). 2024 Jan 1;32(1):38-55. doi: 10.4062/biomolther.2023.054.
6
Lucialdehyde B suppresses proliferation and induces mitochondria-dependent apoptosis in nasopharyngeal carcinoma CNE2 cells.吕西亚醛 B 抑制鼻咽癌细胞 CNE2 的增殖并诱导其线粒体依赖性凋亡。
Pharm Biol. 2023 Dec;61(1):918-926. doi: 10.1080/13880209.2023.2220754.
7
Bioinformatics based exploration of hsa-miR-194-5p regulation of CHD4 through PI3K/AKT signal pathway to enhance tumor resistance to apoptosis due to loss of nests and participate in poor prognosis of oral squamous cell carcinoma.基于生物信息学探究hsa-miR-194-5p通过PI3K/AKT信号通路对CHD4的调控，以增强肿瘤因巢丢失导致的抗凋亡能力并参与口腔鳞状细胞癌的不良预后。
Ann Transl Med. 2023 Jan 31;11(2):107. doi: 10.21037/atm-22-6332.
8
FBXW7 Enhances Cisplatin-Induced Apoptosis in Oral Cancer Cell Lines.FBXW7 增强口腔癌细胞系中顺铂诱导的细胞凋亡。
Int Dent J. 2023 Oct;73(5):620-627. doi: 10.1016/j.identj.2022.11.008. Epub 2022 Dec 5.
9
Modern aspects of the use of natural polyphenols in tumor prevention and therapy.天然多酚在肿瘤预防和治疗中应用的现代进展。
Front Cell Dev Biol. 2022 Sep 12;10:1011435. doi: 10.3389/fcell.2022.1011435. eCollection 2022.
一种自维持的纳米平台通过协同激活外源性和内源性凋亡途径逆转了胰腺癌对 TRAIL 的耐药性。
Biomaterials. 2021 May;272:120795. doi: 10.1016/j.biomaterials.2021.120795. Epub 2021 Apr 1.
4
Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines.鼠尾草酸诱导人胃癌细胞系凋亡并抑制Akt/mTOR信号通路
Pharmaceuticals (Basel). 2021 Mar 8;14(3):230. doi: 10.3390/ph14030230.
5
Cluster of differentiation 147 (CD147) expression is linked with thiram induced chondrocyte's apoptosis via Bcl-2/Bax/Caspase-3 signalling in tibial growth plate under chlorogenic acid repercussion.簇分化抗原 147（CD147）的表达与萎锈灵诱导的软骨细胞凋亡有关，这种凋亡是在绿原酸反应下，通过 Bcl-2/Bax/Caspase-3 信号通路发生在胫骨生长板中的。
Ecotoxicol Environ Saf. 2021 Apr 15;213:112059. doi: 10.1016/j.ecoenv.2021.112059. Epub 2021 Feb 27.
6
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
7
Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras-Raf-MAPK signalling.褪黑素通过自噬和 Ras-Raf-MAPK 信号通路抑制内质网应激下的人胃癌细胞存活。
J Cell Mol Med. 2021 Feb;25(3):1480-1492. doi: 10.1111/jcmm.16237. Epub 2020 Dec 25.
8
The Oscillation Amplitude, Not the Frequency of Cytosolic Calcium, Regulates Apoptosis Induction.振荡幅度而非胞质钙的频率调节凋亡诱导。
iScience. 2020 Oct 13;23(11):101671. doi: 10.1016/j.isci.2020.101671. eCollection 2020 Nov 20.
9
Overexpression of PREX1 in oral squamous cell carcinoma indicates poor prognosis.PREX1 在口腔鳞状细胞癌中的过表达预示着不良预后。
J Mol Histol. 2020 Oct;51(5):531-540. doi: 10.1007/s10735-020-09901-9. Epub 2020 Aug 12.
10
Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway.发现新型[1,2,4]三唑并[1,5-a]嘧啶衍生物，通过线粒体途径杀死胃癌细胞。
Eur J Med Chem. 2020 Oct 1;203:112630. doi: 10.1016/j.ejmech.2020.112630. Epub 2020 Jul 12.