Eltokhy Amira Kamel, Khattab Haidy Abdelaziz, Rabah Hanem Mohamed
Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
Physiology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
J Diabetes Metab Disord. 2021 Jun 18;20(2):1119-1128. doi: 10.1007/s40200-021-00828-w. eCollection 2021 Dec.
Diabetes mellitus (DM) and obesity comorbidity signify a frequent metabolic disorder representing a huge public health burden. Metformin, the most used anti-diabetic medication, is found to reduce body weight via growth differentiation factor 15 (GDF-15) signalling pathways. The medicinal herb Cichorium intybus L. (chicory or cichorium) has a promising pharmacological impact on energy homeostasis. On the other hands, little data is available on its role in DM and obesity. Despite its irrefutable effect, its exact mechanism of action has not completely elucidated; the present study evaluated the effect of chicory on DM, antioxidant status, inflammation, and GDF-15 level in comparison with the metformin effect.
Eighty albino mice were grouped as (control, obese diabetic group, metformin-treated, and Cichorium intybus L -treated group). The study assessed blood glucose, lipid profile, inflammatory markers (IL-6, TNF-α), total antioxidant capacity (TAC) and caspase-3. Quantitative RT-PCR assessed GDF-15 and leptin relative mRNA expression.
Cichorium intybus L has significantly lowered inflammatory, apoptotic markers, and leptin levels compared with the diseased group. Likewise, the plant upregulated GDF-15 and TAC's levels. The study documented a non-significant difference between the Cichorium intybus L -treated and the metformin-treated groups in all estimated markers.
The Cichorium intybus L is a promising herbal supplement with anti-inflammatory, antioxidant, anti-diabetic, and weight reduction effects via affecting GDF-15 signalling pathways.
GDF-15 has anti-inflammatory, anti-oxidative stress and anti-apoptotic effect in DM and obesity via targeting NF-κB mechanisms.
糖尿病（DM）与肥胖症合并存在是一种常见的代谢紊乱疾病，给公共卫生带来了巨大负担。二甲双胍是最常用的抗糖尿病药物，已发现其可通过生长分化因子15（GDF - 15）信号通路减轻体重。药用植物菊苣对能量平衡具有显著的药理作用。另一方面，关于其在糖尿病和肥胖症中的作用的数据较少。尽管其效果确凿，但其确切作用机制尚未完全阐明；本研究评估了菊苣与二甲双胍相比，对糖尿病、抗氧化状态、炎症和GDF - 15水平的影响。
将80只白化小鼠分为（对照组、肥胖糖尿病组、二甲双胍治疗组和菊苣治疗组）。该研究评估了血糖、血脂、炎症标志物（IL - 6、TNF - α）、总抗氧化能力（TAC）和半胱天冬酶 - 3。定量逆转录聚合酶链反应（qRT - PCR）评估GDF - 15和瘦素的相对mRNA表达。
与患病组相比，菊苣显著降低了炎症、凋亡标志物和瘦素水平。同样，该植物上调了GDF - 15和TAC的水平。该研究记录了菊苣治疗组和二甲双胍治疗组在所有评估指标上无显著差异。
菊苣是一种有前景的草药补充剂，通过影响GDF - 15信号通路具有抗炎、抗氧化、抗糖尿病和减肥作用。
GDF - 15通过靶向核因子κB（NF - κB）机制在糖尿病和肥胖症中具有抗炎、抗氧化应激和抗凋亡作用。
