Mirzaei Ahmadreza, Shahrestanaki Ehsan, Daneshzad Elnaz, Heshmati Javad, Djalalinia Shirin, Asayesh Hamid, Mahdavi-Gorabi Armita, Heshmat Ramin, Qorbani Mostafa
Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
J Diabetes Metab Disord. 2021 Aug 11;20(2):1327-1336. doi: 10.1007/s40200-021-00861-9. eCollection 2021 Dec.
The aim of this updated systematic review and meta-analysis was the association between hyperglycemia and periodontitis.
We searched PubMed/MEDLINE, Web of Science, and Scopus until March 2021. The key search words were based on "periodontitis" and "hyperglycemia." We included cohort, case-control, and cross-sectional studies, restricted to publications in English. The quality assessment of included studies and data extraction were done by two independent reviewers. Meta-analysis was performed for cross-sectional studies using the random-effects model.
The literature search yielded 340 studies, and finally, 19 and 11 studies were included in systematic review and meta-analysis, respectively. The total sample size of the eligible studies in the meta-analysis was 38,896 participants, of whom 33% were male with a mean age of 51.20 ± 14.0 years. According to a random-effect meta-analysis in cross-sectional studies, the pooled odds ratio (OR) for the association between hyperglycemia and periodontal indices was statistically significant (OR: 1.50, 95%CI: 1.11, 1.90). There was evidence of publication bias (coefficient: - 3.53, p-value = 0.014) which, after imputing missing studies, the pooled OR of the association between hyperglycemia and periodontitis change to 1.55 (95%CI: 1.20, 1.90).
Results of the present study show that hyperglycemia was positively associated with periodontitis. However, more cohort and prospective longitudinal studies should be conducted to find the exact association. Overall, it seems the management of hyperglycemia could be considered as a preventive strategy for periodontitis.
The online version contains supplementary material available at 10.1007/s40200-021-00861-9.
本项更新的系统评价和荟萃分析旨在研究高血糖与牙周炎之间的关联。
我们检索了截至2021年3月的PubMed/MEDLINE、Web of Science和Scopus数据库。关键检索词基于“牙周炎”和“高血糖”。我们纳入了队列研究、病例对照研究和横断面研究，仅限于英文出版物。纳入研究的质量评估和数据提取由两名独立的评审员完成。对横断面研究采用随机效应模型进行荟萃分析。
文献检索共获得340项研究，最终分别有19项和11项研究纳入系统评价和荟萃分析。荟萃分析中符合条件的研究总样本量为38,896名参与者，其中33%为男性，平均年龄为51.20±14.0岁。根据横断面研究的随机效应荟萃分析，高血糖与牙周指标之间关联的合并比值比（OR）具有统计学意义（OR：1.50，95%CI：1.11，1.90）。存在发表偏倚的证据（系数：-3.53，p值=0.014），在推算缺失研究后，高血糖与牙周炎之间关联的合并OR变为1.55（95%CI：1.20，1.90）。
本研究结果表明，高血糖与牙周炎呈正相关。然而，应开展更多的队列研究和前瞻性纵向研究以明确确切关联。总体而言，似乎控制高血糖可被视为牙周炎的一种预防策略。
在线版本包含可在10.1007/s40200-021-00861-9获取的补充材料。
