Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboudumc Research Institute for Medical innovation (RIMI), Radboud University Medical Center, Nijmegen, Netherlands.
Department of Medical Biochemistry and Molecular Biology, Kilimanjaro Christian Medical University College, Moshi, United Republic of Tanzania.
Elife. 2023 Aug 9;12:e82297. doi: 10.7554/eLife.82297.
Non-communicable diseases (NCDs) are rising rapidly in urbanizing populations in sub-Saharan Africa. Assessment of inflammatory and metabolic characteristics of a urbanizing African population and the comparison with populations outside Africa could provide insight in the pathophysiology of the rapidly increasing epidemic of NCDs, including the role of environmental and dietary changes. Using a proteomic plasma profiling approach comprising 92 inflammation-related molecules, we examined differences in the inflammatory proteome in healthy Tanzanian and healthy Dutch adults. We show that healthy Tanzanians display a pro-inflammatory phenotype compared to Dutch subjects, with enhanced activity of the Wnt/β-catenin signalling pathway and higher concentrations of different metabolic regulators such as 4E-BP1 and fibroblast growth factor 21. Among the Tanzanian volunteers, food-derived metabolites were identified as an important driver of variation in inflammation-related molecules, emphasizing the potential importance of lifestyle changes. These findings endorse the importance of the current dietary transition and the inclusion of underrepresented populations in systems immunology studies.
在撒哈拉以南非洲的城市化人群中，非传染性疾病（NCDs）正在迅速上升。评估城市化非洲人群的炎症和代谢特征，并将其与非洲以外的人群进行比较，可以深入了解 NCDs 迅速流行的病理生理学，包括环境和饮食变化的作用。我们使用包含 92 种炎症相关分子的蛋白质组血浆分析方法，研究了坦桑尼亚和荷兰健康成年人之间炎症蛋白质组的差异。结果显示，与荷兰人相比，坦桑尼亚人表现出促炎表型，Wnt/β-连环蛋白信号通路活性增强，不同代谢调节剂如 4E-BP1 和成纤维细胞生长因子 21 的浓度更高。在坦桑尼亚志愿者中，食物衍生的代谢物被确定为炎症相关分子变化的重要驱动因素，强调了生活方式改变的潜在重要性。这些发现证实了当前饮食转变的重要性，并强调了在系统免疫学研究中纳入代表性不足的人群的重要性。
