大蒜素单独及与抗真菌药物联合对从头癣患者分离出的[具体病原体未给出]的活性
Activity of Allicin Alone and in Combination With Antifungal Drugs Against Isolated From Patients With Tinea Capitis.
作者信息
Zhou Ya Bin, Xiao Yuan Yuan, Chao Jin Jing, Ma Lin
机构信息
Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
出版信息
Front Med (Lausanne). 2021 Nov 26;8:783086. doi: 10.3389/fmed.2021.783086. eCollection 2021.
The checkerboard broth method based on the Clinical and Laboratory Standards Institute M38-A3 document was used in this study to evaluate the activity of allicin alone and in combination with the antifungal drugs (griseofulvin, fluconazole, itraconazole and terbinafine) against isolated from patients with tinea capitis. When allicin was used alone, only weak anti- effects were found. The MIC, MIC and geometric mean (GM) of terbinafine were the lowest among the compounds tested. Synergism was observed for the combinations of allicin with itraconazole and terbinafine. Only indifference was observed for the combinations of allicin with griseofulvin and fluconazole. Our study illustrated the synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to .
本研究采用基于临床和实验室标准协会M38 - A3文件的棋盘肉汤法，评估大蒜素单独及与抗真菌药物（灰黄霉素、氟康唑、伊曲康唑和特比萘芬）联合对从头癣患者分离出的[具体真菌未提及]的活性。当单独使用大蒜素时，仅发现微弱的抗[真菌]作用。在测试的化合物中，特比萘芬的最低抑菌浓度（MIC）、最低杀菌浓度（MBC）和几何均值（GM）最低。观察到大蒜素与伊曲康唑和特比萘芬联合具有协同作用。大蒜素与灰黄霉素和氟康唑联合仅观察到无相互作用。我们的研究表明大蒜素与伊曲康唑和特比萘芬联合具有协同作用，这可为治疗由[具体真菌未提及]引起的头癣提供参考。
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