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首例来自猫的对特比萘芬耐药的犬小孢子菌的报告。

The first report of terbinafine resistance Microsporum canis from a cat.

作者信息

Hsiao Yun-Hsia, Chen Charles, Han Hock Siew, Kano Rui

机构信息

Asian Veterinary Specialist Referral Center, 1F, No. 109, Sec. 4, XingYi Rd. Taipei, 106, Taiwan.

42 JLN Ponderosa 1/9, TMN Ponderosa, 81100 Johor Bahru, Johor, Malaysia.

出版信息

J Vet Med Sci. 2018 Jun 6;80(6):898-900. doi: 10.1292/jvms.17-0680. Epub 2018 Apr 16.

Abstract

A 2-year-old, exotic shorthair cat presented with baldness and mild scaling on trunk that was confirmed as Microsporum canis (M. canis) infection by the following methods. Wood's lamp and trichogram were used to demonstrate fungal elements suggestive of dermatophytosis consistent with M. canis. Dermatophyte test medium (DTM) and polymerase chain reaction (PCR) were used for identification. E-test and broth microdilution test were then utilized to estimate antifungal minimal inhibitory concentrations (MICs) towards ITZ and TRF respectively. The strain was isolated from the patient and revealed TRF MIC >32 µg/ml and ITZ MIC 0.023 µg/ml. Patient was cured of dermatophytosis with systemic ITZ.

摘要

一只2岁的异国短毛猫出现躯干秃毛和轻度脱屑,通过以下方法确诊为犬小孢子菌(M. canis)感染。使用伍德灯和毛发检查来显示提示与犬小孢子菌一致的皮肤癣菌病的真菌成分。使用皮肤癣菌测试培养基(DTM)和聚合酶链反应(PCR)进行鉴定。然后分别使用E-test和肉汤微量稀释试验来估计对伊曲康唑(ITZ)和特比萘芬(TRF)的抗真菌最低抑菌浓度(MIC)。从患者身上分离出该菌株,结果显示特比萘芬MIC>32μg/ml,伊曲康唑MIC为0.023μg/ml。患者通过口服伊曲康唑治愈了皮肤癣菌病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e3/6021895/e40ec409eedf/jvms-80-898-g001.jpg

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