Lin Eric Chang-Yi, Chen Shuoh-Wen, Chen Luen-Kui, Lin Ting-An, Wu Yu-Xuan, Juan Chi-Chang, Chang Yuan-I
Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Department of Internal Medicine, School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan.
Front Nutr. 2021 Nov 10;8:762363. doi: 10.3389/fnut.2021.762363. eCollection 2021.
Glucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We found that GlcN promoted the production of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs), both and . Additionally, GlcN upregulated the expression of glucose transporter 1 in hematopoietic stem and progenitor cells (HSPCs), influenced HSPC functions, and downregulated key genes involved in myelopoiesis. Furthermore, GlcN increased the expression of arginase 1 and inducible nitric oxide synthase to produce high levels of reactive oxygen species, which was regulated by the STAT3 and ERK1/2 pathways, to increase the immunosuppressive ability of MDSCs. We revealed a novel role for GlcN in myelopoiesis and MDSC activity involving a potential link between GlcN and immune system, as well as the new therapeutic benefit.
氨基葡萄糖（GlcN）是消费最为广泛的膳食补充剂，具有抗炎作用。然而，GlcN对免疫细胞生成和功能的影响在很大程度上尚不清楚。在本研究中，将GlcN导入小鼠体内以检测其在造血过程中的生物学功能。我们发现，GlcN促进了未成熟髓样细胞的产生，即髓样来源的抑制细胞（MDSCs），无论是在体内还是体外。此外，GlcN上调了造血干细胞和祖细胞（HSPCs）中葡萄糖转运蛋白1的表达，影响了HSPCs的功能，并下调了参与髓系造血的关键基因。此外，GlcN增加了精氨酸酶1和诱导型一氧化氮合酶的表达，以产生高水平的活性氧，这由STAT3和ERK1/2信号通路调控，从而增强了MDSCs的免疫抑制能力。我们揭示了GlcN在髓系造血和MDSC活性中的新作用，涉及GlcN与免疫系统之间的潜在联系以及新的治疗益处。
