Ramsey-Goldman R, Hom D, Deng J S, Ziegler G C, Kahl L E, Steen V D, LaPorte R E, Medsger T A
Arthritis Rheum. 1986 Oct;29(10):1269-73. doi: 10.1002/art.1780291013.
In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti-SS-A antibody and the 108 without anti-SS-A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti-SS-A and was associated with high-titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti-SS-A antibody was present.
在155例系统性红斑狼疮女性患者中，47例（30%）血清抗SS - A抗体阳性者与108例抗SS - A抗体阴性者在生育能力或不良胎儿结局发生率方面无显著差异，但先天性心脏传导阻滞的发生率除外。这种并发症在抗SS - A抗体阳性女性的96次妊娠中有6例发生，且与母体高滴度抗体有关。狼疮女性生育先天性心脏传导阻滞婴儿的总体风险估计为1:60，但如果存在抗SS - A抗体，风险则显著更高（1:20）。
