Assari Raheleh, Ziaee Vahid, Moradinejad Mohammad-Hassan, Mirmohammadsadeghi Arash
Growth and Development Research Center.
Pediatric Rheumatology Research Group, Rheumatology Research Center ; Department of Pediatrics ; Children's Medical Center, Pediatrics Center of Excellence.
Iran J Pediatr. 2014 Aug;24(4):445-8. Epub 2014 May 16.
Neonatal lupus erythematosus (NLE) is a transient autoimmune disease of developing fetus and neonate in mothers with systemic lupus erythematosus (SLE). In this report we introduce an infant with NLE whose mother had rheumatoid arthritis.
Our case was a 40 day old male infant with discoid-like and annular skin lesions over forehead and neck, irritability and low grade fever. There was a history of prematurity due to preeclampsia. There was no cytopenia or cardiac involvement but liver enzymes were more than 5-fold increased. FANA, Anti Ro and La were negative. The mother had a history of un-controlled rheumatoid arthritis for 12 years with deformity in metacarpal and PIP and ulnar deviation in hands. FANA=1/640 and anti-SSB/La was positive in the mother but there was no other clinical and paraclinical sign of SLE. Without any treatment and during months, the skin and mucosal lesions gradually disappeared without any scar and liver enzymes reached the normal level. After 6 months follow up, he was symptom free with normal growth and development.
We recommend to check anti SSA/Ro and anti SSB/La antibodies in all pregnant women with connective tissue diseases to prevent life-threatening involvement of the infant.
新生儿红斑狼疮（NLE）是患有系统性红斑狼疮（SLE）母亲体内发育中的胎儿及新生儿的一种暂时性自身免疫性疾病。在本报告中，我们介绍了一名母亲患有类风湿关节炎的NLE婴儿。
我们的病例是一名40日龄男婴，前额和颈部有盘状及环形皮肤损害，易激惹且低热。有因子痫前期导致的早产史。无血细胞减少或心脏受累，但肝酶升高超过5倍。荧光抗核抗体（FANA）、抗Ro和抗La均为阴性。母亲有12年未控制的类风湿关节炎病史，掌骨和近端指间关节（PIP）畸形，手部尺侧偏斜。母亲的FANA = 1/640且抗SSB/La阳性，但无其他SLE的临床及实验室检查证据。未经任何治疗，数月内皮肤和黏膜损害逐渐消失，无瘢痕形成，肝酶恢复正常水平。随访6个月后，他无症状，生长发育正常。
我们建议对所有患有结缔组织病的孕妇检测抗SSA/Ro和抗SSB/La抗体，以预防危及婴儿生命的情况发生。
