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本文引用的文献

1
Correlation between obesity and pelvic organ prolapse in Korean women.韩国女性肥胖与盆腔器官脱垂之间的相关性。
Obstet Gynecol Sci. 2020 Nov;63(6):719-725. doi: 10.5468/ogs.19075. Epub 2020 Jul 22.
2
Surgical decision making for symptomatic pelvic organ prolapse: evidence-based approach.有症状盆腔器官脱垂的手术决策：循证方法
Obstet Gynecol Sci. 2019 Sep;62(5):307-312. doi: 10.5468/ogs.2019.62.5.307. Epub 2019 Jul 22.
3
Pelvic organ prolapse: A primer for urologists.盆腔器官脱垂：泌尿外科医生入门指南
Can Urol Assoc J. 2017 Jun;11(6Suppl2):S125-S130. doi: 10.5489/cuaj.4634.
4
Differential expression profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases in females with or without pelvic organ prolapse.有或无盆腔器官脱垂女性中基质金属蛋白酶及其组织抑制剂的差异表达谱分析。
Mol Med Rep. 2014 Oct;10(4):2004-8. doi: 10.3892/mmr.2014.2467. Epub 2014 Aug 8.
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Prevalence, risk factors, and predictors of pelvic organ prolapse: a community-based study.盆腔器官脱垂的患病率、危险因素和预测因素：一项基于社区的研究。
Menopause. 2012 Nov;19(11):1235-41. doi: 10.1097/gme.0b013e31826d2d94.
6
Increased expression of matrix metalloproteinase-1 in uterosacral ligament tissue from women with pelvic organ prolapse.基质金属蛋白酶-1 在盆腔器官脱垂患者的子宫骶韧带组织中的表达增加。
Acta Obstet Gynecol Scand. 2010 Jun;89(6):832-4. doi: 10.3109/00016341003592545.
7
Etiology of pelvic organ prolapse.盆腔器官脱垂的病因
Clin Obstet Gynecol. 2005 Sep;48(3):639-47. doi: 10.1097/01.grf.0000170428.45819.4e.
8
Impact of menopause on collagen subtypes in the arcus tendineous fasciae pelvis.更年期对骨盆腱膜弓中胶原亚型的影响。
Am J Obstet Gynecol. 2004 Mar;190(3):620-7. doi: 10.1016/j.ajog.2003.08.040.
9
Changes in extracellular matrix proteins in the cardinal ligaments of post-menopausal women with or without prolapse: a computerized immunohistomorphometric analysis.有或无子宫脱垂的绝经后女性主韧带中细胞外基质蛋白的变化：一项计算机免疫组织形态计量分析
Hum Reprod. 2003 Oct;18(10):2189-95. doi: 10.1093/humrep/deg420.
10
Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse.压力性尿失禁和盆腔器官脱垂女性的胶原蛋白代谢与更新
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子宫脱垂患者骶子宫韧带基质金属蛋白酶9表达与金属蛋白酶组织抑制因子-1表达的相关性

Correlation between the expression of matrix metalloproteinase 9 and the expression of tissue inhibitor of metalloproteinase-1 of uterosacral ligament in uterine prolapse.

作者信息

Santoso Dhanny Primantara Johari, Purwara Benny Hasan, Achmad Eppy Darmadi

机构信息

Department of Obstetrics and Gynaecology, Dr. Hasan Sadikin Hospital Bandung, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

出版信息

Obstet Gynecol Sci. 2022 Jan;65(1):46-51. doi: 10.5468/ogs.21156. Epub 2021 Dec 14.

DOI:10.5468/ogs.21156
PMID:34902892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8784936/
Abstract

OBJECTIVE

This study aimed to analyze the correlation between the immunoexpression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TiMP1) in the uterosacral ligaments in patients with uterine prolapse.

METHODS

This analytic-correlative cross-sectional study included 32 patients who were admitted at the Hasan Sadikin General Hospital from July to December 2013. Sixteen of the patients had uterine prolapse, while the rest did not. The patients underwent total hysterectomy, radical hysterectomy, or staging laparotomy. MMP-9 and TiMP1 expression in the uterosacral ligaments was measured via immunohistochemical staining. The median expression per field of view was calculated using a histoscore.

RESULTS

MMP-9 expression in patients with uterine prolapse was found to be higher than that in the control group. Meanwhile, TiMP1 expression showed no significant difference between the groups. Spearman's analysis showed a moderate correlation between the expression of MMP-9 and uterine prolapse incidence (P=0.02), with a correlation coefficient of 0.574.

CONCLUSION

There is a moderate correlation between MMP-9 expression and the incidence of uterine prolapse. It can be considered one of the primary etiologies of uterine prolapse.

摘要

目的

本研究旨在分析子宫脱垂患者子宫骶韧带中基质金属蛋白酶9（MMP-9）和金属蛋白酶组织抑制剂-1（TiMP1）的免疫表达之间的相关性。

方法

这项分析相关性横断面研究纳入了2013年7月至12月在哈桑·萨迪金综合医院收治的32例患者。其中16例患者患有子宫脱垂，其余患者未患此病。患者接受了全子宫切除术、根治性子宫切除术或分期剖腹手术。通过免疫组织化学染色测量子宫骶韧带中MMP-9和TiMP1的表达。使用组织评分计算每个视野的中位表达。

结果

发现子宫脱垂患者中MMP-9的表达高于对照组。同时，两组之间TiMP1的表达无显著差异。Spearman分析显示MMP-9的表达与子宫脱垂发生率之间存在中度相关性（P=0.02），相关系数为0.574。

结论

MMP-9的表达与子宫脱垂的发生率之间存在中度相关性。它可被视为子宫脱垂的主要病因之一。