Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
BMJ Open. 2021 Dec 13;11(12):e051397. doi: 10.1136/bmjopen-2021-051397.
The National Colorectal Cancer Cohort (NCRCC) study aims to specifically assess risk factors and biomarkers related to endpoints across the colorectal cancer continuum from the aetiology through survivorship.
The NCRCC study includes the Colorectal Cancer Screening Cohort (CRCSC), which recruited individuals who were at high risk of CRC between 2016 and 2020 and Colorectal Cancer Patients Cohort (CRCPC), which recruited newly diagnosed patients with CRC between 2015 and 2020. Data collection was based on questionnaires and abstraction from electronic medical record. Items included demographic and lifestyle factors, clinical information, survivorship endpoints and other information. Multiple biospecimens including blood, tissue and urine samples were collected. Participants in CRCSC were followed by a combination of periodic survey every 5 years and annual linkage with regional or national cancer and death registries for at least 10 years. In CRCPC, follow-up was conducted with both active and passive approaches at 6, 12, 18, 24, 36, 48 and 60 months after surgery.
A total of 19 377 participants and 15 551 patients with CRC were recruited in CRCSC and in CRCPC, respectively. In CRCSC, 48.0% were men, and the average age of participants at enrolment was 58.7±8.3 years. In CRCPC, 61.4% were men, and the average age was 60.3±12.3 years with 18.9% of participants under 50 years of age.
Longitudinal data and biospecimens will continue to be collected. Based on the cohorts, several studies to assess risk factors and biomarkers for CRC or its survivorship will be conducted, ultimately providing research evidence from Chinese population and optimising evidence-based guidelines across the CRC continuum.
国家结直肠癌队列研究（NCRCC）旨在专门评估结直肠癌连续体从病因学到生存期间与终点相关的风险因素和生物标志物。
NCRCC 研究包括结直肠癌筛查队列（CRCSC），该队列招募了 2016 年至 2020 年期间结直肠癌高危人群，以及结直肠癌患者队列（CRCPC），该队列招募了 2015 年至 2020 年期间新诊断的结直肠癌患者。数据收集基于问卷和电子病历摘录。项目包括人口统计学和生活方式因素、临床信息、生存终点和其他信息。收集了多种生物样本，包括血液、组织和尿液样本。CRCSC 的参与者通过每 5 年定期调查和每年与区域或国家癌症和死亡登记处进行联系相结合进行随访，至少随访 10 年。在 CRCPC 中，通过术后 6、12、18、24、36、48 和 60 个月的主动和被动随访进行随访。
CRCSC 和 CRCPC 分别招募了 19377 名参与者和 15551 名结直肠癌患者。在 CRCSC 中，48.0%为男性，参与者入组时的平均年龄为 58.7±8.3 岁。在 CRCPC 中，61.4%为男性，平均年龄为 60.3±12.3 岁，其中 18.9%的参与者年龄在 50 岁以下。
将继续收集纵向数据和生物样本。基于这些队列，将进行几项研究来评估结直肠癌或其生存的风险因素和生物标志物，最终从中国人群中提供研究证据，并优化结直肠癌连续体的循证指南。
