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纵向测定的肺功能变化与横断面评估的下降情况比较。克拉科夫研究。

Changes in lung function determined longitudinally compared with decline assessed cross-sectionally. The Cracow Study.

作者信息

Jedrychowski W, Krzyzanowski M, Wysocki M

出版信息

Eur J Epidemiol. 1986 Jun;2(2):134-8. doi: 10.1007/BF00157025.

DOI:10.1007/BF00157025
PMID:3490397
Abstract

Longitudinal annual changes in lung function (FEV1) with cross-sectional estimates have been compared in the sample of Cracow inhabitants who underwent epidemiological follow-up on chronic nonspecific chest diseases. The annual rate of FEV1 decline was faster in men than in women. Among male smokers the FEV1 decline rate was 30% greater, while in women smokers 9% faster than in non-smokers. The cross-sectional estimates for annual changes differed in both surveys carried out in the interval of 13 years and were not very much consistent with the average longitudinal annual decline observed in the sample. However, the prediction of annual decline across the age groups showed large inconsistencies. They resulted from the curvilinear pattern in lung function decline over the age groups. It was found that the lung function in the elderly appeared to be more homogeneous and the acceleration of decline rates slowed down. There is some evidence that the flattening of the decline curve among elderly might have been influenced by the selection bias.

摘要

在对患有慢性非特异性胸部疾病的克拉科夫居民样本进行流行病学随访的过程中,对肺功能(第一秒用力呼气容积,FEV1)的纵向年度变化与横断面估计值进行了比较。男性FEV1的年下降率比女性更快。在男性吸烟者中,FEV1下降率比不吸烟者高30%,而在女性吸烟者中则比不吸烟者快9%。在13年间隔内进行的两项调查中,年度变化的横断面估计值有所不同,并且与样本中观察到的平均纵向年度下降情况不太一致。然而,各年龄组年度下降的预测显示出很大的不一致性。这些不一致性源于各年龄组肺功能下降的曲线模式。研究发现,老年人的肺功能似乎更具同质性,下降率的加速减缓。有证据表明,老年人下降曲线的变平可能受到了选择偏倚的影响。

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本文引用的文献

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[Standard spirometric values of FVC,FEV1, FEF25-75%, FEF50-75% and FEF200-1200 estimated in random sample of healthy nonsmokers (author's transl)].在健康非吸烟者随机样本中估算的FVC、FEV1、FEF25 - 75%、FEF50 - 75%和FEF200 - 1200的标准肺量计值(作者译)
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Noncomparability of longitudinally and cross-sectionally determined annual change in spirometry.肺功能测定中纵向和横断面测定的年度变化的不可比性。
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