Suppr超能文献

抗Lyt 2抗体对T细胞上Lyt 2抗原表达的体内调节：对刀豆蛋白A诱导的无反应性的影响。

Modulation in vivo of Lyt 2 antigen expression on T cells by anti-Lyt 2 antibody: effects on Con A-induced unresponsiveness.

作者信息

MacDonald T T, Calkins C E, Rothermel A L

出版信息

Immunology. 1986 Oct;59(2):181-6.

PMID:3490432
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453174/
Abstract

After a series of intraperitoneal injections of rat monoclonal anti-Lyt 2 antibody supernatant, BDF1 mice showed a loss of cells bearing Lyt 2 surface antigens but no reduction in the numbers of T cells in the spleen. With overnight culture in vitro, splenic T cells from anti-Lyt 2-treated mice regenerated surface Lyt 2, with the proportion of Lyt 2+ cells returning to control levels. Anti-rat IgG antibody was found in the serum of mice that had received the anti-Lyt 2 treatments. Modulation of the surface Lyt 2 antigens was demonstrable in vitro but only in the presence of mouse anti-rat IgG antibody. Functionally, this series of in vivo anti-Lyt 2 antibody treatments substantially reversed Con A-induced suppression of the anti-sheep red blood cell antibody response.

摘要

在对BDF1小鼠进行一系列腹腔注射大鼠单克隆抗Lyt 2抗体上清液后，小鼠脾脏中带有Lyt 2表面抗原的细胞数量减少，但T细胞数量未减少。经过体外过夜培养，接受抗Lyt 2处理的小鼠脾脏T细胞表面重新生成Lyt 2，Lyt 2+细胞比例恢复到对照水平。在接受抗Lyt 2处理的小鼠血清中发现了抗大鼠IgG抗体。表面Lyt 2抗原的调节在体外可以证实，但仅在存在小鼠抗大鼠IgG抗体的情况下。在功能上，这一系列体内抗Lyt 2抗体处理显著逆转了伴刀豆球蛋白A诱导的对抗绵羊红细胞抗体反应的抑制作用。

相似文献

1
Modulation in vivo of Lyt 2 antigen expression on T cells by anti-Lyt 2 antibody: effects on Con A-induced unresponsiveness.抗Lyt 2抗体对T细胞上Lyt 2抗原表达的体内调节：对刀豆蛋白A诱导的无反应性的影响。
Immunology. 1986 Oct;59(2):181-6.
2
Lyt-2+ cells. Requirements for concanavalin A-induced proliferation and interleukin 2 production.Lyt-2+细胞。刀豆球蛋白A诱导增殖及白细胞介素2产生的条件。
J Immunol. 1987 Nov 1;139(9):2880-7.
3
Interleukin 2 induces both, growth and maturation of lectin reactive Lyt-2+ but not Lyt-2-precursor cells and regulates the cytolytic potential of effector cells.白细胞介素2可诱导凝集素反应性Lyt-2+细胞而非Lyt-2-前体细胞的生长和成熟，并调节效应细胞的细胞溶解潜能。
Immunobiology. 1986 Apr;171(3):274-301. doi: 10.1016/S0171-2985(86)80010-9.
4
Con A-induced TCGF-reactivity is selectively acquired by Lyt-2-positive T cell precursors.刀豆球蛋白A诱导的TCGF反应性是由Lyt-2阳性T细胞前体选择性获得的。
J Immunol. 1983 Jul;131(1):19-22.
5
Crossreactivity of anti Lyt-2.2 monoclonal antibody with some Lyt-2.2-negative mouse strains.
Arch Immunol Ther Exp (Warsz). 1987;35(4):511-7.
6
Positively selected Lyt-2+ and Lyt-2- mouse T lymphocytes are comparable, after Con A stimulation, in release of IL 2 and of lymphokines acting on B cells, macrophages, and mast cells, but differ in interferon production.在伴刀豆球蛋白A刺激后，经阳性选择的Lyt-2⁺和Lyt-2⁻小鼠T淋巴细胞在白细胞介素2以及作用于B细胞、巨噬细胞和肥大细胞的淋巴因子释放方面相当，但在干扰素产生方面存在差异。
J Immunol. 1983 May;130(5):2225-30.
7
The growth of concanavalin-A activated, Lyt selected subsets in IL-2 containing supernatants.伴刀豆球蛋白A激活的、Lyt选择的亚群在含白细胞介素-2的上清液中的生长。
Immunobiology. 1984 Oct;167(4):365-75. doi: 10.1016/S0171-2985(84)80008-X.
8
Differential effect of two monoclonal anti-Lyt-1 alloantibodies on lymphocyte distribution in vivo.两种抗Lyt-1单克隆同种抗体对体内淋巴细胞分布的不同作用。
Immunology. 1984 Jun;52(2):325-30.
9
Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis.在特定T细胞亚群耗竭的小鼠中诱导自身免疫性甲状腺炎。I. 诱导甲状腺炎对Lyt-1迟钝L3T4明亮正常T细胞的需求。
J Immunol. 1988 Jul 1;141(1):105-13.
10
The functional association of Lyt antigens with lymphokine production.Lyt抗原与淋巴因子产生的功能关联。
Immunology. 1985 Jan;54(1):25-33.

引用本文的文献

1
Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response.急性病毒感染的恢复机制：用单克隆抗体治疗淋巴细胞性脉络丛脑膜炎病毒感染的小鼠表明，Lyt-2 + T淋巴细胞介导病毒清除并调节抗病毒抗体反应。
J Virol. 1987 Jun;61(6):1867-74. doi: 10.1128/JVI.61.6.1867-1874.1987.

本文引用的文献

1
Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes: analysis by antibody blocking and selective trypsinization.细胞毒性T淋巴细胞上Lyt-2/3分子功能需求的克隆异质性：通过抗体阻断和选择性胰蛋白酶消化进行分析。
J Exp Med. 1982 Dec 1;156(6):1711-22. doi: 10.1084/jem.156.6.1711.
2
LFA-1 but not Lyt-2 is associated with killing activity of cytotoxic T lymphocyte hybridomas.淋巴细胞功能相关抗原-1（LFA-1）而非Lyt-2与细胞毒性T淋巴细胞杂交瘤的杀伤活性相关。
Nature. 1982 Nov 25;300(5890):357-60. doi: 10.1038/300357a0.
3
Blocking effect of lyt-2 antibodies on T cell functions.Lyt-2抗体对T细胞功能的阻断作用。
J Exp Med. 1980 Sep 1;152(3):674-87. doi: 10.1084/jem.152.3.674.
4
Lyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis.一个克隆的细胞溶解T细胞系的Lyt-2-/Lyt 3-变体缺乏在细胞溶解中起作用的抗原受体。
J Exp Med. 1981 Mar 1;153(3):595-604. doi: 10.1084/jem.153.3.595.
5
In-vivo modulation of thymus-derived lymphocytes with monoclonal antibodies in mice. I. Effect of anti-Thy-1 antibody on the tissue distribution of lymphocytes.小鼠体内用单克隆抗体对胸腺来源淋巴细胞的调节。I. 抗Thy-1抗体对淋巴细胞组织分布的影响。
Immunology. 1983 Dec;50(4):537-46.
6
Inhibition of T cell-mediated cytolysis by monoclonal antibodies directed against Lyt-2: heterogeneity of inhibition at the clonal level.针对Lyt-2的单克隆抗体对T细胞介导的细胞溶解作用的抑制：克隆水平上抑制作用的异质性
J Immunol. 1981 May;126(5):1671-5.
7
In vivo administration of anti-I-A antibody induces the internalization of B cell surface I-A and I-E without affecting the expression of surface immunoglobulin.体内给予抗I-A抗体可诱导B细胞表面I-A和I-E内化，而不影响表面免疫球蛋白的表达。
J Immunol. 1984 Jul;133(1):91-7.
8
The mechanism of CTL-mediated killing: monoclonal antibody analysis of the roles of killer and target-cell membrane proteins.细胞毒性T淋巴细胞（CTL）介导杀伤的机制：杀伤细胞和靶细胞膜蛋白作用的单克隆抗体分析
Immunol Rev. 1983;72:73-96. doi: 10.1111/j.1600-065x.1983.tb01073.x.
9
A study of the mechanism of Con A-induced immunosuppression in vivo.体内伴刀豆球蛋白A诱导免疫抑制机制的研究。
Cell Immunol. 1984 Aug;87(1):147-58. doi: 10.1016/0008-8749(84)90139-4.
10
The lateral mobility and surface distribution of Lyt-1, Lyt-2 and Lyt-3 on mouse thymocytes.Lyt-1、Lyt-2和Lyt-3在小鼠胸腺细胞上的侧向迁移率及表面分布
Mol Immunol. 1982 Nov;19(11):1481-9. doi: 10.1016/0161-5890(82)90194-8.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验