Faculty of Nursing, Université de Montréal, Montreal, QC, Canada.
CHU Sainte-Justine Research Centre, Montreal, QC, Canada.
JBI Evid Synth. 2021 Dec;19(12):3340-3346. doi: 10.11124/JBIES-20-00336.
This systematic review will assess the association between painful procedures performed on preterm infants while hospitalized in the neonatal intensive care unit and short-, mid-, and long-term neurodevelopmental outcomes.
Preterm infants hospitalized in the neonatal unit undergo many painful procedures. The repetition of these painful procedures in a preterm infant with an immature nervous system can have consequences for their neurodevelopment.
Prospective and retrospective observational study designs will be included in this review. Studies of preterm infants (less than 37 weeks of gestation) hospitalized in the neonatal intensive care unit who have undergone painful procedures, with or without skin breaking, will be considered for inclusion in this review. Our main variable will be neurodevelopment, measured in the short, medium, and long term.
A comprehensive database search will be undertaken in CINAHL, PubMed, MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. We will limit the search to articles published in English or French. Study selection, data extraction, and critical appraisal will be conducted by two independent reviewers. If possible, meta-analysis will be performed; otherwise the results will be presented by descriptive synthesis.
PROSPERO CRD42020189762.
本系统评价将评估在新生儿重症监护病房住院的早产儿接受的疼痛性操作与短期、中期和长期神经发育结局之间的关联。
在新生儿病房住院的早产儿会经历许多疼痛性操作。在神经系统尚未成熟的早产儿身上重复这些疼痛性操作可能会对他们的神经发育产生影响。
本综述将纳入前瞻性和回顾性观察性研究设计。将考虑纳入在新生儿重症监护病房住院并接受疼痛性操作（有或无皮肤破损）的早产儿的研究。我们的主要变量将是短期、中期和长期的神经发育。
将在 CINAHL、PubMed、MEDLINE、Embase 和 Cochrane 对照试验中心注册库中进行全面的数据库检索。我们将把检索范围限制在发表于英语或法语的文章。研究选择、数据提取和批判性评价将由两名独立的评审员进行。如果可能，将进行荟萃分析；否则，将通过描述性综合呈现结果。
PROSPERO CRD42020189762。
