Kubota Risa, Tsushima Tomoyasu, Doi Keisuke, Inoue Yousuke, Shinno Yoko, Ichikawa Takaharu
Department of Urology, National Hospital Organization Okayama Medical Center, Okayama 701-1192, Japan.
Department of Urology, Iwakuni Medical Center, Iwakuni, Yamaguchi 740-8510, Japan.
Mol Clin Oncol. 2022 Jan;16(1):23. doi: 10.3892/mco.2021.2456. Epub 2021 Dec 1.
Pancreatic cancer is not easy to detect at its early stages due to difficulties in identifying symptoms at these stages. As it progresses, abdominal pain, loss of appetite, abdominal distension, jaundice and pain in the back, especially the lower back, might develop. Moreover, sudden onset or worsening of diabetes mellitus may be seen, which often prompts screening for the detection of pancreatic cancer. Since it rapidly spreads to surrounding tissues and organs, pancreatic cancer has a poor prognosis. However, metastasis to the bladder is rare, with few cases diagnosed on the basis of detecting gross hematuria. The current study presents a case of gross hematuria and exacerbated diabetes in a 90-year-old woman. Cystoscopy revealed a non-papillary tumor in the posterior bladder wall. Pathological examination of bladder tumor specimens obtained via transurethral resection revealed adenocarcinoma. Subsequent systemic examinations revealed primary pancreatic cancer that had metastasized to the bladder. To the best of our knowledge, this is the second reported case of pancreatic cancer diagnosed based on the detection of gross hematuria due to bladder metastasis, since 1992.
由于在胰腺癌早期阶段难以识别症状,所以胰腺癌在早期不易被发现。随着病情发展,可能会出现腹痛、食欲不振、腹胀、黄疸以及背部疼痛,尤其是下背部疼痛。此外,可能会出现糖尿病的突然发作或病情恶化,这常常促使人们进行胰腺癌筛查。由于胰腺癌会迅速扩散到周围组织和器官,其预后较差。然而,胰腺癌转移至膀胱的情况罕见,很少有病例是基于肉眼血尿的检测而被诊断出来的。本研究报告了一例90岁女性出现肉眼血尿且糖尿病加重的病例。膀胱镜检查发现膀胱后壁有一个非乳头状肿瘤。经尿道切除获得的膀胱肿瘤标本的病理检查显示为腺癌。随后的全身检查发现原发性胰腺癌已转移至膀胱。据我们所知,这是自1992年以来第二例基于膀胱转移导致肉眼血尿检测而诊断出的胰腺癌病例。