Kimura M, van Rappard-van der Veen F M, Gleichmann E
Clin Exp Immunol. 1986 Sep;65(3):542-52.
The effect of various H-2-subregion differences on graft-versus-host (GVH) autoimmunity in mice was investigated by testing a variety of GVH combinations in which non-irradiated adult F1 hybrid mice were injected with parental strain lymphoid cells. As with previous results, the superiority of Class-II H-2 antigen (I-A/I-E) differences to other kinds of H-2 incompatibilities, such as Class-I H-2 antigen (H-2K/H-2D) differences, was largely confirmed. Anti-nuclear antibodies were produced significantly across Class-I as well as Class-II H-2 differences. However, the productions of anti-erythrocyte and anti-thymocyte autoantibodies were mainly confined to GVH reactions induced across Class-II H-2 antigens. Elevated proteinuria was elicited only in the GVH combinations that included the differences at Class-II H-2 antigens. GVH autoimmunity, however, did not always result in the significant occurrence of elevated proteinuria. The level of in-vitro IgG production by GVH spleen cells correlated closely with the degree of autoimmunity.
通过检测多种移植物抗宿主（GVH）组合来研究不同H-2亚区差异对小鼠GVH自身免疫的影响，在这些组合中，未受照射的成年F1杂交小鼠被注射亲代品系淋巴细胞。与先前的结果一样，II类H-2抗原（I-A/I-E）差异相对于其他类型的H-2不相容性（如I类H-2抗原（H-2K/H-2D）差异）的优势在很大程度上得到了证实。I类和II类H-2差异均显著产生抗核抗体。然而，抗红细胞和抗胸腺细胞自身抗体的产生主要局限于由II类H-2抗原引发的GVH反应。仅在包含II类H-2抗原差异的GVH组合中引发蛋白尿升高。然而，GVH自身免疫并不总是导致蛋白尿显著升高。GVH脾细胞的体外IgG产生水平与自身免疫程度密切相关。
