发生移植物抗宿主反应的F1小鼠诱导产生的抗核抗体的特异性：同种型和交叉反应性。
Specificity of anti-nuclear antibodies induced in F1 mice undergoing the graft-vs-host reaction: isotypes and cross-reactivities.
作者信息
Kimura M, Ida S, Shimada K, Kanai Y
机构信息
Department of Internal Medicine, University of Tokyo, Japan.
出版信息
Clin Exp Immunol. 1987 Aug;69(2):385-93.
(C57BL/6 X DBA/2)F1 mice undergoing the graft-vs-host reaction (GVHR) produce autoantibodies after the injection of DBA/2 lymphoid cells. The anti-nuclear antibodies, including anti-poly (ADP-ribose) and anti-extractable nuclear antigens (ENA), in the sera of the autoimmune GVH F1 mice were investigated. Antibodies to double-stranded DNA, single-stranded DNA and ENA were predominantly IgG. In contrast, the autoantibodies to poly(ADP-ribose) were both IgG and IgM, although the former was predominant. These autoantibodies induced by the GVHR showed similar cross-reactivities with a number of nucleic acids to the monoclonal and some serum antinuclear antibodies derived from mice or humans with systemic lupus erythematosus (SLE). These results support the idea that GVH F1 mice are a good model of human SLE.
经历移植物抗宿主反应（GVHR）的（C57BL/6×DBA/2）F1小鼠在注射DBA/2淋巴细胞后会产生自身抗体。对自身免疫性GVH F1小鼠血清中的抗核抗体，包括抗聚（ADP-核糖）抗体和抗可提取核抗原（ENA）抗体进行了研究。抗双链DNA、单链DNA和ENA抗体主要为IgG。相比之下，抗聚（ADP-核糖）自身抗体既有IgG也有IgM，尽管前者占主导。由GVHR诱导的这些自身抗体与多种核酸的交叉反应性，与来自患有系统性红斑狼疮（SLE）的小鼠或人类的单克隆及一些血清抗核抗体相似。这些结果支持了GVH F1小鼠是人类SLE良好模型的观点。
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