手术导致的免疫反应抑制。豚鼠模型。
Depression of immunological responses due to surgery. A model in the guinea-pig.
作者信息
Cooper A J, Irvine J M, Turnbull A R
出版信息
Immunology. 1974 Sep;27(3):393-9.
Abstract
The responses of guinea-pigs to sensitization immediately following cholecystectomy (as a standard surgical procedure) are significantly depressed. Generation of memory function on stimulation with sheep erythrocytes is radically impaired; the effect is also more marked in primary delayed hypersensitivity and thymus-dependent antibody responses than in the response to pneumococcal polysaccharide. Normal lymphocyte transfer tests using operated animals as recipients or donors are not depressed. The evidence is suggestive of dysfunction in the amplification or co-operative stages of immune responses in the early post-operative period.
摘要
豚鼠在胆囊切除术后（作为一种标准外科手术）立即进行致敏的反应明显受到抑制。用绵羊红细胞刺激时记忆功能的产生受到根本损害；在原发性迟发型超敏反应和胸腺依赖性抗体反应中，这种影响比在对肺炎球菌多糖的反应中更明显。使用手术动物作为受体或供体的正常淋巴细胞转移试验并未受到抑制。证据表明在术后早期免疫反应的放大或协同阶段存在功能障碍。
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引用本文的文献
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Appearance of spontaneously Ig secreting B cells in human peripheral blood after surgery.手术后人体外周血中自发分泌免疫球蛋白的B细胞的出现。
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Studies on artifical antigens. I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.人工抗原的研究。I. 二硝基苯-聚赖氨酸及赖氨酸与谷氨酸的二硝基苯共聚物在豚鼠体内的抗原性
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Postoperative depression of the lymphocyte response to phytohaemagglutinin.
Lancet. 1967 Apr 8;1(7493):746-8. doi: 10.1016/s0140-6736(67)91364-5.
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