Gao Yikui, Li Cong, Li Xiaoyun, Zhang Minghong
Ophthalmology Department, The Eighth People's Hospital of Qingdao, Qingdao 266000, China.
Refraction Department, Qingdao Aier Eye Hospital, Qingdao 266400, China.
Open Life Sci. 2021 Dec 3;16(1):1261-1267. doi: 10.1515/biol-2021-0111. eCollection 2021.
The term fatty keratopathy is used to describe the phenomenon of fat deposition caused by corneal neovascularization, which will severely affect the eye's beauty and vision. The purpose of this study was to establish a New Zealand white rabbit animal model of fatty keratopathy, that is, the establishment of an animal model of fatty keratopathy. The goal was achieved by the combination of a corneal neovascularization animal model and a hyperlipidemia animal model. Two groups were created according to the experimental sequence. The first group initially induced a corneal neovascularization pattern and later induced a hyperlipidemia pattern, and the second group followed the opposite sequence. The results of the two groups showed that all the significant crystalline deposits of the cornea were visible. So the animal models of fatty keratopathy were successfully established in both groups.
脂肪性角膜病变一词用于描述由角膜新生血管化引起的脂肪沉积现象，这将严重影响眼睛的美观和视力。本研究的目的是建立脂肪性角膜病变的新西兰白兔动物模型，即建立脂肪性角膜病变的动物模型。通过将角膜新生血管化动物模型和高脂血症动物模型相结合来实现这一目标。根据实验顺序创建了两组。第一组最初诱导角膜新生血管化模式，随后诱导高脂血症模式，第二组则遵循相反的顺序。两组结果均显示角膜上所有明显的晶体沉积物都可见。因此，两组均成功建立了脂肪性角膜病变的动物模型。
