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氯化铷对躁郁症病程的影响。

Effects of rubidium chloride on the course of manic-depressive illness.

作者信息

Paschalis C, Jenner F A, Lee C R

出版信息

J R Soc Med. 1978 May;71(5):343-52. doi: 10.1177/014107687807100507.

Abstract

Clinical studies of the effects of rubidium ions on the course of manic-depressive illness are reported. It seems that rubidium tends to increase the length of manic phases and possibly reduces the extremes of mood. Rubidium did not seem to produce any severe side effects in the dose administered, but it has a long biological half-life and caution is still required. Some details of the CSF, RBC, saliva and plasma and urine kinetics are also reported.

摘要

本文报道了铷离子对躁郁症病程影响的临床研究。铷似乎会延长躁狂期的时长,并可能减轻情绪的极端波动。在所使用的剂量下,铷似乎未产生任何严重的副作用,但它具有较长的生物半衰期,仍需谨慎使用。文中还报告了脑脊液、红细胞、唾液、血浆及尿液动力学的一些细节。

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本文引用的文献

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A comparison of the distribution of 42K and 86Rb in rabbit and man.兔与人体内42K和86Rb分布的比较。
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Effect of lithium on foot shock aggression in rats.
Nature. 1970 Oct 17;228(5268):284-5. doi: 10.1038/228284a0.
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Brain norepinephrine: enhanced turnover after rubidium treatment.
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