人红细胞中活性钾转运的浓度依赖性
The concentration dependence of active potassium transport in the human red blood cell.
作者信息
Sachs J R, Welt L G
出版信息
J Clin Invest. 1967 Jan;46(1):65-76. doi: 10.1172/JCI105512.
Abstract
The relation between the active potassium influx in the human red blood cell and the extracellular potassium concentration does not appear to be consistent with the Michaelis-Menten model, but is adequately described by a model in which two potassium ions are required simultaneously at some site or sites in the transport mechanism before transport occurs. The same type of relation appears to exist between that portion of the sodium outflux that requires the presence of extracellular potassium and the extracellular potassium concentration. Rubidium, cesium, and lithium, which are apparently transported by the same system that transports potassium, stimulate the potassium influx when both potassium and the second ion are present at low concentrations, as is predicted by the two-site model.
摘要
人体红细胞中钾离子的主动内流与细胞外钾离子浓度之间的关系似乎并不符合米氏模型，而是可以用一个模型来充分描述，即在转运发生之前，转运机制中的某个位点或某些位点需要同时存在两个钾离子。在需要细胞外钾离子存在的那部分钠离子外流与细胞外钾离子浓度之间，似乎也存在相同类型的关系。铷、铯和锂显然是通过与转运钾离子相同的系统进行转运的，当钾离子和第二种离子都处于低浓度时，它们会刺激钾离子内流，这正如双位点模型所预测的那样。
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