Baron J C, D'Antona R, Pantano P, Serdaru M, Samson Y, Bousser M G
Brain. 1986 Dec;109 ( Pt 6):1243-59. doi: 10.1093/brain/109.6.1243.
Positron emission tomography was used to study the effects of unilateral vascular thalamic lesions on cortical oxygen and glucose utilization in 10 patients. There was significant ipsilateral cortex hypometabolism in 9 of the 10 patients, affecting the whole cortical mantle diffusely. The only patient spared was free of neuropsychological deficit at the time of positron emission tomography. In 4 patients, the magnitude of ipsilateral cortical hypometabolism was significantly less at a follow-up PET study, when neuropsychological function had improved. When taken together, the 14 studies showed a significant tendency for the hypometabolism to improve with time after clinical onset. These data suggest that the ipsilateral cortical hypometabolism results from damage to the thalamocortical connections and reflect either loss of nonspecific activating afferences or a degenerative deafferentation-deafferentation process, or both. Its links with the concept of diaschisis are suggested by its tendency to recover. A causal relationship between cortical hypometabolism and neuropsychological deficit, however, although strongly suggested, cannot be firmly established from the present data.
正电子发射断层扫描技术被用于研究10例患者单侧丘脑血管性病变对皮质氧和葡萄糖利用的影响。10例患者中有9例出现同侧皮质明显代谢减退，累及整个皮质。唯一未受累的患者在进行正电子发射断层扫描时没有神经心理学缺陷。在4例患者中，随访正电子发射断层扫描研究时，神经心理学功能改善，同侧皮质代谢减退的程度明显减轻。综合这14项研究表明，临床发病后，代谢减退有随时间改善的显著趋势。这些数据表明，同侧皮质代谢减退是丘脑皮质连接受损的结果，反映了非特异性激活传入纤维的丧失或退行性去传入-去传入过程，或两者兼有。其恢复的趋势提示了它与远隔性机能障碍概念的联系。然而，尽管目前的数据强烈提示皮质代谢减退与神经心理学缺陷之间存在因果关系，但尚不能确凿地证实。
