Modlin R L, Ormerod L D, Walsh G P, Rea T H, Meyers W M, Binford C H, Martin L N, Wolf R H, Gormus B J
Clin Exp Immunol. 1986 Aug;65(2):260-4.
Leprosy in the mangabey monkey is an experimental model which is similar both clinically and histologically to human lepromatous leprosy. The immunopathology of these diseases was compared using monoclonal antibodies against T lymphocyte subpopulations in frozen tissue sections with an immunoperoxidase technique. In both mangabey and human lepromatous granulomas OKT4 (or Leu 3a) and Leu 2a cells were scattered among macrophages with greater numbers of Leu 2a as compared with OKT4 (or Leu 3a) cells. The results suggest that from an immunopathological standpoint experimental leprosy in mangabeys will provide a suitable model for the investigation of the pathogenesis of human lepromatous leprosy and for the evaluation of new antileprosy vaccines.
白睑猴的麻风病是一种实验模型，在临床和组织学上都与人类瘤型麻风相似。使用抗T淋巴细胞亚群的单克隆抗体，通过免疫过氧化物酶技术，对冷冻组织切片中这些疾病的免疫病理学进行了比较。在白睑猴和人类瘤型肉芽肿中，OKT4（或Leu 3a）和Leu 2a细胞散布于巨噬细胞之间，与OKT4（或Leu 3a）细胞相比，Leu 2a细胞数量更多。结果表明，从免疫病理学角度来看，白睑猴的实验性麻风病将为研究人类瘤型麻风的发病机制以及评估新型抗麻风疫苗提供一个合适的模型。
