• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Editorial: Codon Usage and Dinucleotide Composition of Virus Genomes: From the Virus-Host Interaction to the Development of Vaccines.

作者信息

Pintó Rosa M, Burns Cara C, Moratorio Gonzalo

机构信息

Enteric Virus Laboratory, Section of Microbiology, Virology and Biotechnology, Department of Genetics, Microbiology and Statistics, School of Biology, University of Barcelona, Barcelona, Spain.

Division of Viral Disease, Molecular Epidemiology and Surveillance, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States.

出版信息

Front Microbiol. 2021 Nov 30;12:791750. doi: 10.3389/fmicb.2021.791750. eCollection 2021.

DOI:10.3389/fmicb.2021.791750
PMID:34917065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8671033/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d7/8671033/cf6781fdb1de/fmicb-12-791750-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d7/8671033/cf6781fdb1de/fmicb-12-791750-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d7/8671033/cf6781fdb1de/fmicb-12-791750-g0001.jpg

相似文献

1
Editorial: Codon Usage and Dinucleotide Composition of Virus Genomes: From the Virus-Host Interaction to the Development of Vaccines.社论:病毒基因组的密码子使用和二核苷酸组成:从病毒 - 宿主相互作用到疫苗开发
Front Microbiol. 2021 Nov 30;12:791750. doi: 10.3389/fmicb.2021.791750. eCollection 2021.
2
Edging on Mutational Bias, Induced Natural Selection From Host and Natural Reservoirs Predominates Codon Usage Evolution in Hantaan Virus.受突变偏向性影响,来自宿主和天然宿主库的诱导自然选择主导了汉坦病毒密码子使用的进化。
Front Microbiol. 2021 Jul 2;12:699788. doi: 10.3389/fmicb.2021.699788. eCollection 2021.
3
Hepatitis A Virus Codon Usage: Implications for Translation Kinetics and Capsid Folding.甲型肝炎病毒密码子使用:对翻译动力学和衣壳折叠的影响。
Cold Spring Harb Perspect Med. 2018 Oct 1;8(10):a031781. doi: 10.1101/cshperspect.a031781.
4
Fine-tuning translation kinetics selection as the driving force of codon usage bias in the hepatitis A virus capsid.微调翻译动力学选择作为甲型肝炎病毒衣壳中密码子使用偏性的驱动力。
PLoS Pathog. 2010 Mar 5;6(3):e1000797. doi: 10.1371/journal.ppat.1000797.
5
Codon Usage Optimization in the Prokaryotic Tree of Life: How Synonymous Codons Are Differentially Selected in Sequence Domains with Different Expression Levels and Degrees of Conservation.原核生物树中的密码子使用优化:具有不同表达水平和不同保守程度的序列结构域中如何差异选择同义密码子。
mBio. 2020 Jul 21;11(4):e00766-20. doi: 10.1128/mBio.00766-20.
6
Effect of genome composition and codon bias on infectious bronchitis virus evolution and adaptation to target tissues.基因组组成和密码子偏好对传染性支气管炎病毒进化和适应靶组织的影响。
BMC Genomics. 2021 Apr 7;22(1):244. doi: 10.1186/s12864-021-07559-5.
7
Genetic and codon usage bias analyses of major capsid protein gene in Ranavirus.虹彩病毒主要衣壳蛋白基因的遗传和密码子使用偏性分析。
Infect Genet Evol. 2020 Oct;84:104379. doi: 10.1016/j.meegid.2020.104379. Epub 2020 Jun 1.
8
Analysis of synonymous codon usage in enterovirus 71.肠道病毒71型同义密码子使用情况分析
Virusdisease. 2014;25(2):243-8. doi: 10.1007/s13337-014-0215-y. Epub 2014 May 21.
9
Pandemic influenza A virus codon usage revisited: biases, adaptation and implications for vaccine strain development.甲型流感病毒的密码子使用偏好分析:偏性、适应性及其对疫苗株选育的影响。
Virol J. 2012 Nov 8;9:263. doi: 10.1186/1743-422X-9-263.
10
Variability in Codon Usage in Coronaviruses Is Mainly Driven by Mutational Bias and Selective Constraints on CpG Dinucleotide.冠状病毒密码子使用偏好的变异性主要由突变偏倚和对 CpG 二核苷酸的选择限制驱动。
Viruses. 2021 Sep 10;13(9):1800. doi: 10.3390/v13091800.

引用本文的文献

1
Codon Usage Evolution in Viruses: Implications for Survival and Pathogenicity.病毒中的密码子使用进化:对生存和致病性的影响
J Mol Evol. 2025 Sep 4. doi: 10.1007/s00239-025-10263-7.
2
Suboptimal dengue genome leverages non-canonical translation mechanisms.次优登革热基因组利用非经典翻译机制。
iScience. 2025 Apr 15;28(5):112428. doi: 10.1016/j.isci.2025.112428. eCollection 2025 May 16.
3
Natural Selection Shaped Codon Usage Patterns in Wheat Dwarf Virus in Triticale.自然选择塑造了小黑麦中小麦矮缩病毒的密码子使用模式。

本文引用的文献

1
Assessment of genetic changes and neurovirulence of shed Sabin and novel type 2 oral polio vaccine viruses.对排出的萨宾株及新型2型口服脊髓灰质炎疫苗病毒的基因变化和神经毒力的评估。
NPJ Vaccines. 2021 Jul 29;6(1):94. doi: 10.1038/s41541-021-00355-y.
2
The Codon Usage Code for Cotranslational Folding of Viral Capsids.病毒衣壳共翻译折叠的密码子使用代码。
Genome Biol Evol. 2021 Sep 1;13(9). doi: 10.1093/gbe/evab089.
3
Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in healthy adults: two clinical trials.
Biology (Basel). 2025 May 9;14(5):524. doi: 10.3390/biology14050524.
4
Insight into the codon usage patterns and adaptation of Tembusu Virus.对坦布苏病毒密码子使用模式及适应性的洞察。
Poult Sci. 2025 Jan;104(1):104651. doi: 10.1016/j.psj.2024.104651. Epub 2024 Dec 7.
5
SARS-CoV-2 Displays a Suboptimal Codon Usage Bias for Efficient Translation in Human Cells Diverted by Hijacking the tRNA Epitranscriptome.SARS-CoV-2 在人类细胞中表现出低效的翻译密码子使用偏性,这种偏性是通过劫持 tRNA 表观转录组实现的。
Int J Mol Sci. 2024 Oct 29;25(21):11614. doi: 10.3390/ijms252111614.
6
A Synthetic Biology Approach for Vaccine Candidate Design against Delta Strain of SARS-CoV-2 Revealed Disruption of Favored Codon Pair as a Better Strategy over Using Rare Codons.一种针对新冠病毒Delta毒株的候选疫苗设计的合成生物学方法表明,破坏偏好密码子对是比使用稀有密码子更好的策略。
Vaccines (Basel). 2023 Feb 20;11(2):487. doi: 10.3390/vaccines11020487.
7
Current landscape and future directions of synthetic biology in South America.南美洲合成生物学的现状与未来发展方向
Front Bioeng Biotechnol. 2023 Feb 10;11:1069628. doi: 10.3389/fbioe.2023.1069628. eCollection 2023.
在健康成人中,将两种新型2型口服脊髓灰质炎病毒疫苗候选株与单价2型口服脊髓灰质炎病毒疫苗的安全性和免疫原性进行比较:两项临床试验
Lancet. 2021 Jan 2;397(10268):39-50. doi: 10.1016/S0140-6736(20)32541-1. Epub 2020 Dec 9.
4
Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in children and infants: two clinical trials.两种新型 2 型口服脊髓灰质炎疫苗候选物与单价 2 型口服脊髓灰质炎疫苗在儿童和婴儿中的安全性和免疫原性比较:两项临床试验。
Lancet. 2021 Jan 2;397(10268):27-38. doi: 10.1016/S0140-6736(20)32540-X. Epub 2020 Dec 9.
5
Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization.利用密码子去优化技术开发用于根除脊髓灰质炎最终阶段的新型口服脊髓灰质炎疫苗。
NPJ Vaccines. 2020 Mar 20;5(1):26. doi: 10.1038/s41541-020-0176-7. eCollection 2020.
6
Dissimilation of synonymous codon usage bias in virus-host coevolution due to translational selection.由于翻译选择,病毒-宿主共同进化中同义密码子使用偏好的异化。
Nat Ecol Evol. 2020 Apr;4(4):589-600. doi: 10.1038/s41559-020-1124-7. Epub 2020 Mar 2.
7
The Critical Role of Codon Composition on the Translation Efficiency Robustness of the Hepatitis A Virus Capsid.密码子组成对甲型肝炎病毒衣壳翻译效率稳健性的关键作用。
Genome Biol Evol. 2019 Sep 1;11(9):2439-2456. doi: 10.1093/gbe/evz146.
8
Chikungunya Virus Vaccine Candidates with Decreased Mutational Robustness Are Attenuated and Have Compromised Transmissibility.具有降低突变稳健性的基孔肯雅病毒候选疫苗减毒且传播能力受损。
J Virol. 2019 Aug 28;93(18). doi: 10.1128/JVI.00775-19. Print 2019 Sep 15.
9
The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 study.两种新型口服减毒单价(血清型 2)脊灰病毒疫苗在健康成年人中的安全性和免疫原性:一项双盲、单中心 1 期研究。
Lancet. 2019 Jul 13;394(10193):148-158. doi: 10.1016/S0140-6736(19)31279-6. Epub 2019 Jun 4.
10
Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.全球同义突变鉴定出调控 HIV-1 剪接和复制的顺式作用 RNA 元件。
PLoS Pathog. 2018 Jan 29;14(1):e1006824. doi: 10.1371/journal.ppat.1006824. eCollection 2018 Jan.