人畜共患病溢出：人类感染适应 mink 的 SARS-CoV-2 病毒。
Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans.
机构信息
Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdańsk, Poland.
Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.
出版信息
Clin Microbiol Infect. 2022 Mar;28(3):451.e1-451.e4. doi: 10.1016/j.cmi.2021.12.001. Epub 2021 Dec 15.
OBJECTIVES
This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months.
METHODS
Next-generation sequencing and a bioinformatic approach were applied to analyse the data.
RESULTS
In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others.
CONCLUSIONS
Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.
目的
本研究旨在分析严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）可能存在的人畜共患病溢出风险。我们报告了在适应至少 3 个月后，养殖水貂适应的 SARS-CoV-2 从水貂溢出传染给人类。
方法
采用下一代测序和生物信息学方法分析数据。
结果
在从一名 SARS-CoV-2 检测呈阳性的无症状患者中获得的分离株中，我们在 S 基因中发现了四个导致水貂适应变体的区别性突变（G75V、M177T、Y453F 和 C1247F）和其他突变。
结论
SARS-CoV-2 可以从水貂传染给人类，发生人畜共患病溢出。
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