Faculty of Biotechnology of University of Gdansk and Medical University of Gdansk, Gdańsk, Poland.
Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.
Clin Microbiol Infect. 2022 Mar;28(3):451.e1-451.e4. doi: 10.1016/j.cmi.2021.12.001. Epub 2021 Dec 15.
This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months.
Next-generation sequencing and a bioinformatic approach were applied to analyse the data.
In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others.
Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.
本研究旨在分析严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）可能存在的人畜共患病溢出风险。我们报告了在适应至少 3 个月后，养殖水貂适应的 SARS-CoV-2 从水貂溢出传染给人类。
采用下一代测序和生物信息学方法分析数据。
在从一名 SARS-CoV-2 检测呈阳性的无症状患者中获得的分离株中，我们在 S 基因中发现了四个导致水貂适应变体的区别性突变（G75V、M177T、Y453F 和 C1247F）和其他突变。
SARS-CoV-2 可以从水貂传染给人类，发生人畜共患病溢出。
