Momose T, Kunimoto M, Nishikawa J, Kasaka N, Ohtake T, Iio M
Radiat Med. 1986 Apr-Jun;4(2):46-50.
We studied a patient with hyperhidrosis and electroencephalographic (EEG) abnormality using N-isopropyl I-123 p-iodoamphetamine (I-123 IMP) with single photon emission computed tomography (SPECT). EEG abnormality was found predominantly in the frontal area, and sharp wave bursts were induced by hyperventilation. Ictal and nonictal scans were obtained with simultaneous EEG recordings. Ictal scans revealed increased uptake of IMP in the frontal cortex, reflecting hyperperfusion to the frontal area. The ratio of IMP uptake of the frontal to the parietal cortex (F/P ratio) was calculated both in the ictal and nonictal phase. In the ictal phase, the F/P ratio was 1.23, compared with 0.91 in the nonictal phase. The data indicated altered regional cerebral blood flow with EEG abnormality and hyperventilation load. Although the relationship between sweating and cortical function is not fully understood, our study indicates that excessive mental sweating is related to frontal cortical dysfunction. I-123 IMP-SPECT seems valuable for topographical demonstration of epileptogenic lesions and understanding the pathophysiological process of mental sweating.
我们使用N-异丙基I-123对碘安非他明（I-123 IMP）和单光子发射计算机断层扫描（SPECT）对一名患有多汗症和脑电图（EEG）异常的患者进行了研究。EEG异常主要出现在额叶区域，过度换气可诱发尖波爆发。在同步记录EEG的情况下进行发作期和发作间期扫描。发作期扫描显示额叶皮质对IMP的摄取增加，反映了额叶区域的血流灌注过多。计算了发作期和发作间期额叶与顶叶皮质的IMP摄取比值（F/P比值）。发作期F/P比值为1.23，而发作间期为0.91。数据表明，EEG异常和过度换气负荷会导致局部脑血流改变。虽然出汗与皮质功能之间的关系尚未完全明确，但我们的研究表明，精神性多汗与额叶皮质功能障碍有关。I-123 IMP-SPECT对于癫痫病灶的定位显示以及理解精神性出汗的病理生理过程似乎具有重要价值。
