Lee R G, Hill T C, Holman B L, Uren R, Clouse M E
Radiology. 1982 Dec;145(3):789-93. doi: 10.1148/radiology.145.3.6983088.
N-isopropyl (I-123) p-iodoamphetamine (IMP), which is extracted by the brain in proportion to regional blood flow, has been shown to be useful with single-photon emission tomography (SPECT) in the assessment of pathologic states related to blood flow. Because emission tomographic equipment is not yet available at most hospitals, the authors compared IMP brain images obtained with an Anger camera with those obtained by SPECT to determine the usefulness of IMP scintigraphy. Thirty-nine pairs of studies were performed on 12 control patients, 14 patients with stroke, three patients with tumors, and a miscellaneous group of eight patients. Planar scintigraphy showed good correlation with SPECT in determining the presence or absence of abnormality in all patients except one with a very small brain stem infarction that was not detected by planar imaging. Anger images showed poor contrast resolution compared with SPECT images. It is thus expected that SPECT will result in better lesion detection when smaller lesions are studied. Planar scintigraphy is not capable of providing quantitative measurement of regional cerebral blood flow.
N-异丙基（I-123）对碘安非他明（IMP）可按区域血流比例被脑摄取，已证明其在单光子发射断层扫描（SPECT）评估与血流相关的病理状态时很有用。由于大多数医院尚无发射断层扫描设备，作者将用安格尔相机获得的IMP脑图像与SPECT获得的图像进行比较，以确定IMP闪烁扫描的实用性。对12名对照患者、14名中风患者、3名肿瘤患者以及8名其他杂类患者进行了39组研究。平面闪烁扫描在除1名脑干梗死灶极小而平面成像未检测到的患者外的所有患者中，在确定有无异常方面与SPECT显示出良好的相关性。与SPECT图像相比，安格尔图像的对比分辨率较差。因此，预计在研究较小病灶时SPECT将能更好地检测病变。平面闪烁扫描无法提供局部脑血流的定量测量。
