Zhang Peng, Wang Lei, Chen Xiuying, Li Xiang, Yuan Qinghai
Department of Radiology, The Second Hospital of Jilin University, Changchun, China.
Department of Radiology, Jilin Province FAW General Hospital, Changchun, China.
Front Pharmacol. 2021 Dec 2;12:795012. doi: 10.3389/fphar.2021.795012. eCollection 2021.
Bi-based nanomaterials, such as BiSe, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall BiSe nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). BiSe nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet-visible-near infrared region. Under irradiation at 808 nm, PEI-BiSe nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated and . These results revealed that PEI-BiSe nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.
铋基纳米材料，如硒化铋，在生物医学中发挥着重要作用，如光热疗法（PTT）和计算机断层扫描（CT）成像。使用超快速合成方法在室温（25°C）下制备了聚乙烯亚胺（PEI）修饰的超小硒化铋纳米点。硒化铋纳米点表现出优异的CT成像性能，并且由于其在紫外-可见-近红外区域的广泛吸收，可用作有效的光热试剂。在808nm照射下，PEI-硒化铋纳米点表现出高达41.3%的优异光热转换效率。证明了其良好的生物相容性和显著的肿瘤消融能力。这些结果表明，PEI-硒化铋纳米点是安全的，是用于癌症CT成像引导的光热疗法的良好纳米诊疗平台。
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