State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.
Nanoscale. 2018 Sep 13;10(35):16765-16774. doi: 10.1039/c8nr04870c.
Developing a biocompatible nanotheranostic platform integrating diagnostic and therapeutic functions is a great prospect for cancer treatment. However, it is still a great challenge to synthesize nanotheranostic agents using an ultra-facile method. In the research reported here, ultrasmall polyethylenimine-protected silver bismuth sulfide (PEI-AgBiS2) nanodots were successfully synthesized using an ultra-facile and environmentally friendly strategy (1 min only at room temperature), which could be described as a "rookie method". PEI-AgBiS2 nanodots show good monodispersity and biocompatibility. For the first time, PEI-AgBiS2 nanodots were reported as a powerful and safe nanotheranostic agent for cancer treatment. PEI-AgBiS2 nanodots exhibit excellent computed tomography (CT) and photoacoustic (PA) dual-modal imaging ability, which could effectively guide photothermal cancer therapy. Furthermore, PEI-AgBiS2 nanodots exhibit a high photothermal conversion efficiency (η = 35.2%). The photothermal therapy (PTT) results demonstrated a highly efficient tumor ablation ability. More importantly, the blood biochemistry and histology analyses verify that the PEI-AgBiS2 nanodots have negligible long-term toxicity. This work highlights that PEI-AgBiS2 nanodots produced using this extremely effective method are a high-performance and safe PTT agent. These findings open a new gateway for synthesizing nanotheranostic agents by using this ultra-facile method in the future.
开发集诊断和治疗功能于一体的生物相容性纳米诊疗平台是癌症治疗的一个很有前景的方向。然而，用超简单的方法合成纳米诊疗试剂仍然是一个巨大的挑战。在本研究中，采用超简单且环保的策略（仅在室温下 1 分钟）成功合成了超小的聚乙烯亚胺保护的银铋硫化物（PEI-AgBiS2）纳米点，可以形容为一种“新手方法”。PEI-AgBiS2 纳米点具有良好的单分散性和生物相容性。首次报道了 PEI-AgBiS2 纳米点作为一种强大且安全的用于癌症治疗的纳米诊疗试剂。PEI-AgBiS2 纳米点表现出优异的计算机断层扫描（CT）和光声（PA）双模式成像能力，可有效指导光热癌症治疗。此外，PEI-AgBiS2 纳米点表现出高的光热转换效率（η = 35.2%）。光热治疗（PTT）结果表明具有高效的肿瘤消融能力。更重要的是，血液生化和组织学分析验证了 PEI-AgBiS2 纳米点具有可忽略的长期毒性。这项工作强调了使用这种极其有效的方法制备的 PEI-AgBiS2 纳米点是一种高性能且安全的 PTT 试剂。这些发现为未来通过这种超简单的方法合成纳米诊疗试剂开辟了新的途径。
