Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions , Suzhou 215123, P. R. China.
School of Physics and Electronics, Hunan University , Changsha 410082, P. R. China.
ACS Nano. 2016 Dec 27;10(12):11145-11155. doi: 10.1021/acsnano.6b06067. Epub 2016 Dec 6.
Sub-3 nm ultrasmall BiSe nanodots stabilized with bovine serum albumin were successfully synthesized through a reaction of hydroxyethylthioselenide with bismuth chloride in aqueous solution under ambient conditions. These nanodots exhibit a high photothermal conversion efficiency (η = 50.7%) due to their strong broad absorbance in the near-infrared (NIR) window and serve as a nanotheranostic agent for photoacoustic imaging and photothermal cancer therapy. In addition, they also display radioenhancement with a ratio of 6% due to their sensitivity to X-rays, which makes them a potential sensitizer for radiotherapy. These nanodots were also labled with radioactive Tc for quantification of their biodistribution by single-photon-emission computed tomography (SPECT)/computed tomography (CT) imaging. Our work demonstrates the potential of ultrasmall BiSe nanodots in multimodal imaging-guided synergetic radiophotothermal therapy of cancer.
通过羟乙基硒硫与氯化铋在水溶液中于环境条件下的反应，成功合成了稳定的亚 3nm 超小 BiSe 纳米点。这些纳米点由于在近红外（NIR）窗口具有很强的宽带吸收，表现出很高的光热转换效率（η=50.7%），可用作光声成像和光热癌症治疗的纳米治疗剂。此外，由于它们对 X 射线敏感，还表现出 6%的放射增强作用，这使它们成为放射治疗的潜在增敏剂。这些纳米点还被放射性 Tc 标记，以便通过单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）成像定量其生物分布。我们的工作证明了超小 BiSe 纳米点在癌症的多模态成像引导协同放化疗中的潜力。
