Qing Ming, Qiu Yue, Wang Jiarong, Zheng Tinghui, Yuan Ding
Department of Applied Mechanics, Sichuan University, Chengdu, China.
Yibin Institute of Industrial Technology/Sichuan University Yibin Park, Yibin, China.
Front Physiol. 2021 Dec 2;12:795085. doi: 10.3389/fphys.2021.795085. eCollection 2021.
Cross-limb stent grafts for endovascular aneurysm repair (EVAR) are often employed for abdominal aortic aneurysms (AAAs) with significant aortic neck angulation. Neck angulation may be coronal or sagittal; however, previous hemodynamic studies of cross-limb EVAR stent grafts (SGs) primarily utilized simplified planar neck geometries. This study examined the differences in flow patterns and hemodynamic parameters between crossed and non-crossed limb SGs at different spatial neck angulations. Ideal models consisting of 13 cross and 13 non-cross limbs were established, with coronal and sagittal angles ranging from 0 to 90°. Computational fluid dynamics (CFD) was used to capture the hemodynamic information, and the differences were compared. With regards to the pressure drop index, the maximum difference caused by the configuration and angular direction was 4.6 and 8.0%, respectively, but the difference resulting from the change in aneurysm neck angle can reach 27.1%. With regards to the SAR-TAWSS index, the maximum difference caused by the configuration and angular direction was 7.8 and 9.8%, respectively, but the difference resulting from the change in aneurysm neck angle can reach 26.7%. In addition, when the aneurysm neck angle is lower than 45°, the configuration and angular direction significantly influence the OSI and helical flow intensity index. However, when the aneurysm neck angle is greater than 45°, the hemodynamic differences of each model at the same aneurysm neck angle are reduced. The main factor affecting the hemodynamic index was the angle of the aneurysm neck, while the configuration and angular direction had little effect on the hemodynamics. Furthermore, when the aneurysm neck was greatly angulated, the cross-limb technique did not increase the risk of thrombosis.
用于血管内动脉瘤修复(EVAR)的交叉肢体支架移植物常用于具有明显主动脉颈部成角的腹主动脉瘤(AAA)。颈部成角可能是冠状位或矢状位;然而,先前关于交叉肢体EVAR支架移植物(SGs)的血流动力学研究主要采用简化的平面颈部几何形状。本研究探讨了不同空间颈部成角情况下交叉肢体和非交叉肢体SGs之间的血流模式和血流动力学参数差异。建立了由13个交叉肢体和13个非交叉肢体组成的理想模型,冠状角和矢状角范围为0至90°。采用计算流体动力学(CFD)获取血流动力学信息并进行差异比较。关于压降指数,由构型和角度方向引起的最大差异分别为4.6%和8.0%,但由动脉瘤颈部角度变化引起的差异可达27.1%。关于SAR-TAWSS指数,由构型和角度方向引起的最大差异分别为7.8%和9.8%,但由动脉瘤颈部角度变化引起的差异可达26.7%。此外,当动脉瘤颈部角度低于45°时,构型和角度方向对OSI和螺旋血流强度指数有显著影响。然而,当动脉瘤颈部角度大于45°时,相同动脉瘤颈部角度下各模型的血流动力学差异减小。影响血流动力学指数的主要因素是动脉瘤颈部角度,而构型和角度方向对血流动力学影响较小。此外,当动脉瘤颈部严重成角时,交叉肢体技术不会增加血栓形成风险。