Ersöz Alpaslan, Kim Insoo, Han Martin
Biomedical Engineering Department, University of Connecticut, Storrs, CT 06269 USA.
Department of Medicine and Division of Occupational and Environmental Medicine, University of Connecticut, Farmington, CT 06030 USA.
Int IEEE EMBS Conf Neural Eng. 2021 May;2021:540-543. doi: 10.1109/ner49283.2021.9441282. Epub 2021 Jun 2.
Efficacious stimulation of neural tissues requires high charge injection capacity while minimizing electrode polarization. Applying anodic bias on certain electrode materials is a way to enhance charge injection both and . We developed an embedded neurostimulator system that enabled a digital control of user-defined bias levels, without requiring a potentiometer or external voltage source. Comparison of charge injection with and without anodic-bias, as well as at different bias potentials were conducted in phosphate-buffered saline with Blackrock iridium oxide microelectrodes. Results showed that a nine-fold increase in current intensity and charge injection capacity, was achieved with a 0.7 V anodic bias and within electrochemically safe limits.
对神经组织进行有效的刺激需要高电荷注入能力，同时将电极极化降至最低。在某些电极材料上施加阳极偏压是一种增强电荷注入的方法。我们开发了一种嵌入式神经刺激器系统，该系统能够对用户定义的偏压水平进行数字控制，而无需电位计或外部电压源。使用布莱克罗克氧化铱微电极在磷酸盐缓冲盐水中对有无阳极偏压以及不同偏压电位下的电荷注入进行了比较。结果表明，在0.7V阳极偏压下且在电化学安全范围内，电流强度和电荷注入能力提高了九倍。
