Li Feng, Ye Ying, Lei Xiaohua, Zhang Wensheng
Department of Urinary Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Cam-Su Genomic Resource Center, Medical College of Soochow University, Suzhou, China.
Front Cell Dev Biol. 2021 Dec 2;9:797167. doi: 10.3389/fcell.2021.797167. eCollection 2021.
With the development of science and technology, mankind's exploration of outer space has increased tremendously. Settling in outer space or on other planets could help solve the Earth's resource crisis, but such settlement will first face the problem of reproduction. There are considerable differences between outer space and the Earth's environment, with the effects of gravity being one of the most significant. Studying the possible effects and underlying mechanisms of microgravity on embryonic stem cell (ESC) differentiation and embryonic development could help provide solutions to healthy living and reproduction in deep space. This article summarizes recent research progress on the effects of microgravity on ESCs and early embryonic development and proposes hypotheses regarding the potential mechanisms. In addition, we discuss the controversies and key questions in the field and indicate directions for future research.
随着科学技术的发展，人类对外层空间的探索大幅增加。在外层空间或其他行星上定居有助于解决地球的资源危机，但这种定居首先将面临繁殖问题。外层空间与地球环境存在相当大的差异，重力影响是其中最显著的之一。研究微重力对胚胎干细胞（ESC）分化和胚胎发育的可能影响及潜在机制，有助于为深空健康生活和繁殖提供解决方案。本文总结了微重力对胚胎干细胞和早期胚胎发育影响的最新研究进展，并提出了潜在机制的假设。此外，我们讨论了该领域的争议和关键问题，并指出了未来研究的方向。
