Lopes Guilherme S, Manemann Sheila M, Weston Susan A, Jiang Ruoxiang, Larson Nicholas B, Moser Ethan D, Roger Véronique L, Takahashi Paul Y, Sandoval Yader, Bell Malcolm R, Chamberlain Alanna M, Brewer LaPrincess C, Singh Mandeep, St Sauver Jennifer L, Bielinski Suzette J
Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Mayo Clin Proc Innov Qual Outcomes. 2022 Feb;6(1):77-85. doi: 10.1016/j.mayocpiqo.2021.12.002. Epub 2021 Dec 13.
To study associations between the Minnesota coronavirus disease 2019 (COVID-19) mitigation strategies on incidence rates of acute myocardial infarction (MI) or revascularization among residents of Southeast Minnesota.
Using the Rochester Epidemiology Project, all adult residents of a nine-county region of Southeast Minnesota who had an incident MI or revascularization between January 1, 2015, and December 31, 2020, were identified. Events were defined as primary in-patient diagnosis of MI or undergoing revascularization. We estimated age- and sex-standardized incidence rates and incidence rate ratios (IRRs) stratified by key factors, comparing 2020 to 2015-2019. We also calculated IRRs by periods corresponding to Minnesota's COVID-19 mitigation timeline: "Pre-lockdown" (January 1-March 11, 2020), "First lockdown" (March 12-May 31, 2020), "Between lockdowns" (June 1-November 20, 2020), and "Second lockdown" (November 21-December 31, 2020).
The incidence rate in 2020 was 32% lower than in 2015-2019 (24 vs 36 events/100,000 person-months; IRR, 0.68; 95% CI, 0.62-0.74). Incidence rates were lower in 2020 versus 2015-2019 during the first lockdown (IRR, 0.54; 95% CI, 0.44-0.66), in between lockdowns (IRR, 0.70; 95% CI, 0.61-0.79), and during the second lockdown (IRR, 0.54; 95% CI, 0.41-0.72). April had the lowest IRR (IRR 0.48; 95% CI, 0.34-0.68), followed by August (IRR, 0.55; 95% CI, 0.40-0.76) and December (IRR, 0.56; 95% CI, 0.41-0.77). Similar declines were observed across sex and all age groups, and in both urban and rural residents.
Mitigation measures for COVID-19 were associated with a reduction in hospitalizations for acute MI and revascularization in Southeast Minnesota. The reduction was most pronounced during the lockdown periods but persisted between lockdowns.
研究明尼苏达州2019年冠状病毒病（COVID-19）缓解策略与明尼苏达州东南部居民急性心肌梗死（MI）发病率或血运重建率之间的关联。
利用罗切斯特流行病学项目，确定了2015年1月1日至2020年12月31日期间明尼苏达州东南部一个九县地区发生急性心肌梗死或血运重建的所有成年居民。事件定义为MI的主要住院诊断或接受血运重建。我们估计了按关键因素分层的年龄和性别标准化发病率及发病率比（IRR），将2020年与2015 - 2019年进行比较。我们还按与明尼苏达州COVID - 19缓解时间表对应的时间段计算了IRR：“封锁前”（2020年1月1日至3月11日）、“首次封锁”（2020年3月12日至5月31日）、“两次封锁之间”（2020年6月1日至11月20日）和“第二次封锁”（2020年11月21日至12月31日）。
2020年的发病率比2015 - 2019年低32%（24例对36例/100,000人月；IRR，0.68；95%CI，0.62 - 0.74）。2020年与2015 - 2019年相比，首次封锁期间发病率较低（IRR，0.54；95%CI，0.44 - 0.66），两次封锁之间（IRR，0.70；95%CI，0.61 - 0.79）以及第二次封锁期间（IRR，0.54；95%CI，0.41 - 0.72）发病率也较低。4月的IRR最低（IRR 0.48；95%CI，0.34 - 0.68），其次是8月（IRR，0.55；95%CI，0.40 - 0.76）和12月（IRR，0.56；95%CI，0.41 - 0.77）。在性别和所有年龄组以及城市和农村居民中均观察到类似的下降。
COVID - 19缓解措施与明尼苏达州东南部急性心肌梗死住院率和血运重建率的降低有关。这种降低在封锁期间最为明显，但在两次封锁之间持续存在。
