饮食补充对MRL/lpr小鼠自身免疫的影响：一项初步研究。
Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation.
作者信息
Godfrey D G, Stimson W H, Watson J, Belch J F, Sturrock R D
出版信息
Ann Rheum Dis. 1986 Dec;45(12):1019-24. doi: 10.1136/ard.45.12.1019.
Abstract
The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose oil (EPO), fish oil, and a fish oil/EPO mixture. The mice receiving a diet enriched with EPO showed an increase in survival, as did those receiving the fish oil/EPO mixture. These results, taken together with those of the other parameters monitored, suggest that EPO may be of benefit in alleviating the murine form of the disease.
摘要
研究了在自发性自身免疫性MRL-mp-lpr/lpr系统性红斑狼疮小鼠模型发病前，膳食补充脂肪酸对各种疾病参数的影响。在低脂饮食中补充以下几种油：橄榄油、葵花籽油、月见草油（EPO）、鱼油以及鱼油/月见草油混合物。摄入富含EPO饮食的小鼠存活率有所提高，摄入鱼油/月见草油混合物的小鼠也是如此。这些结果与监测的其他参数结果一起表明，EPO可能有助于减轻该疾病的小鼠发病形式。
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