Jäntti J, Nikkari T, Solakivi T, Vapaatalo H, Isomäki H
Rheumatism Foundation Hospital, Heinola, Finland.
Ann Rheum Dis. 1989 Feb;48(2):124-7. doi: 10.1136/ard.48.2.124.
The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, and arachidonic acid increased during treatment with evening primrose oil. During olive oil treatment the serum concentration of eicosapentaenoic acid decreased and those of high density lipoprotein-cholesterol and apolipoprotein A-I increased slightly. The decrease in serum eicosapentaenoic acid and the increase in arachidonic acid concentrations induced by evening primrose oil may not be favourable effects in patients with rheumatoid arthritis in the light of the roles of these fatty acids as precursors of eicosanoids.
对18例类风湿关节炎患者进行了研究，这些患者分别接受20毫升含9%γ-亚麻酸的月见草油或橄榄油治疗12周，测定了空腹过夜后的血脂浓度和脂肪酸组成。在月见草油治疗期间，油酸、二十碳五烯酸和载脂蛋白B的血清浓度降低，而亚油酸、γ-亚麻酸、二高-γ-亚麻酸和花生四烯酸的血清浓度升高。在橄榄油治疗期间，二十碳五烯酸的血清浓度降低，高密度脂蛋白胆固醇和载脂蛋白A-I的血清浓度略有升高。鉴于这些脂肪酸作为类二十烷酸前体的作用，月见草油引起的血清二十碳五烯酸降低和花生四烯酸浓度升高可能对类风湿关节炎患者并非有益作用。
