Sugano M, Ide T, Ishida T, Yoshida K
Ann Nutr Metab. 1986;30(5):289-99. doi: 10.1159/000177206.
The hypocholesterolemic effect of polyunsaturated fatty acids was compared in male rats given high-cholesterol diets containing either evening primrose oil (EPO, linoleic plus gamma-linolenic), safflower oil (SFO, linoleic) or olive oil (OLO, low linoleic) at the 10% level. EPO with a phytosterol content of 1.47% was found to be more hypocholesterolemic than SFO (phytosterols 0.34%), and rats given EPO excreted more neutral (cholesterol and its metabolites) but not acidic steroids during the first 2 weeks of the feeding. Even when the phytosterol content of EPO and SFO was adjusted to be the same (0.67%), EPO was still more hypocholesterolemic than SFO but to a lesser extent, although fecal neutral steroid excretion was comparable in these two dietary fat regimens. The results indicate a significant hypocholesterolemic efficacy of gamma-linolenic acid.
在给予含10%月见草油（EPO，含亚油酸和γ-亚麻酸）、红花油（SFO，含亚油酸）或橄榄油（OLO，低亚油酸）的高胆固醇饮食的雄性大鼠中，比较了多不饱和脂肪酸的降胆固醇作用。发现植物甾醇含量为1.47%的EPO比植物甾醇含量为0.34%的SFO具有更强的降胆固醇作用，并且在喂食的前两周，给予EPO的大鼠排泄出更多的中性类固醇（胆固醇及其代谢产物），但酸性类固醇排泄量没有增加。即使将EPO和SFO的植物甾醇含量调整为相同（0.67%），EPO的降胆固醇作用仍然比SFO更强，只是程度较小，尽管在这两种膳食脂肪方案中粪便中性类固醇排泄量相当。结果表明γ-亚麻酸具有显著的降胆固醇功效。
