Kitagawa M, Matsubara O, Song S Y, Kurashima C, Okeda R, Kasuga T
Cancer. 1985 Sep 1;56(5):1134-43. doi: 10.1002/1097-0142(19850901)56:5<1134::aid-cncr2820560530>3.0.co;2-j.
Three cases of neoplastic angioendotheliosis (NAE) presenting with central nervous system (CNS) disease but no skin lesions are described. The histogenesis of the neoplastic cells is discussed. Microscopic examination showed accumulation of neoplastic cells in the vascular system throughout the body and their extravascular proliferation in several organs. Electron microscopic and immunohistochemical studies revealed the presence of Weibel-Palade bodies and factor VIII-related antigen in intravascular and extravascular neoplastic cells in two of the three cases. In the first case the neoplastic cells did not have any T-cell markers. However, in one case no specific markers were found in the neoplastic cells by electron microscopic, enzyme histochemical, or immunohistochemical examination. These findings, although supporting the endothelial origin of the neoplastic cells, indicate the need for further consideration of whether NAE is actually a single disease entity or several different diseases.
本文描述了3例以中枢神经系统（CNS）疾病为表现但无皮肤病变的肿瘤性血管内皮增生症（NAE）。文中讨论了肿瘤细胞的组织发生。显微镜检查显示肿瘤细胞在全身血管系统中积聚，并在多个器官中发生血管外增殖。电子显微镜和免疫组织化学研究显示，在3例中的2例中，血管内和血管外肿瘤细胞中存在Weibel-Palade小体和VIII因子相关抗原。在第1例中，肿瘤细胞没有任何T细胞标志物。然而，在1例中，通过电子显微镜、酶组织化学或免疫组织化学检查，在肿瘤细胞中未发现特异性标志物。这些发现虽然支持肿瘤细胞的内皮起源，但表明需要进一步考虑NAE实际上是单一疾病实体还是几种不同疾病。
